Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin

BACKGROUND: Supramolecular micelles as drug-delivery vehicles are generally unable to enter the nucleus of nondividing cells. In the work reported here, nuclear localization signal (NLS)-modified polymeric micelles were studied with the aim of improving nuclear drug delivery. METHODS: In this resear...

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Detalles Bibliográficos
Autores principales: Yu, Jingmou, Xie, Xin, Zheng, Meirong, Yu, Ling, Zhang, Lei, Zhao, Jianguo, Jiang, Dengzhao, Che, Xiangxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459689/
https://www.ncbi.nlm.nih.gov/pubmed/23049255
http://dx.doi.org/10.2147/IJN.S36150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459689/
https://www.ncbi.nlm.nih.gov/pubmed/23049255
http://dx.doi.org/10.2147/IJN.S36150

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