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Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase

In pancreatic β-cells, glutamate dehydrogenase (GDH) modulates insulin secretion, although its function regarding specific secretagogues is unclear. This study investigated the role of GDH using a β-cell–specific GDH knockout mouse model, called βGlud1(−/−). The absence of GDH in islets isolated fro...

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Detalles Bibliográficos
Autores principales:	Vetterli, Laurène, Carobbio, Stefania, Pournourmohammadi, Shirin, Martin-del-Rio, Rafael, Skytt, Dorte M., Waagepetersen, Helle S., Tamarit-Rodriguez, Jorge, Maechler, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459861/ https://www.ncbi.nlm.nih.gov/pubmed/22875990 http://dx.doi.org/10.1091/mbc.E11-08-0676

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