Confidence-based Somatic Mutation Evaluation and Prioritization

Next generation sequencing (NGS) has enabled high throughput discovery of somatic mutations. Detection depends on experimental design, lab platforms, parameters and analysis algorithms. However, NGS-based somatic mutation detection is prone to erroneous calls, with reported validation rates near 54%...

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Detalles Bibliográficos
Autores principales: Löwer, Martin, Renard, Bernhard Y., de Graaf, Jos, Wagner, Meike, Paret, Claudia, Kneip, Christoph, Türeci, Özlem, Diken, Mustafa, Britten, Cedrik, Kreiter, Sebastian, Koslowski, Michael, Castle, John C., Sahin, Ugur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459886/
https://www.ncbi.nlm.nih.gov/pubmed/23028300
http://dx.doi.org/10.1371/journal.pcbi.1002714

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