Cardiomyocyte Aldose Reductase Causes Heart Failure and Impairs Recovery from Ischemia

Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. We investigated whether deleterious effects of AR are due to its actions specifically in cardiomyocytes....

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Detalles Bibliográficos
Autores principales: Son, Ni-Huiping, Ananthakrishnan, Radha, Yu, Shuiqing, Khan, Raffay S., Jiang, Hongfeng, Ji, Ruiping, Akashi, Hirokazu, Li, Qing, O'Shea, Karen, Homma, Shunichi, Goldberg, Ira J., Ramasamy, Ravichandran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459912/
https://www.ncbi.nlm.nih.gov/pubmed/23029549
http://dx.doi.org/10.1371/journal.pone.0046549

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