Ubiquitination and Degradation of the Hominoid-Specific Oncoprotein TBC1D3 Is Mediated by CUL7 E3 Ligase

Expression of the hominoid-specific TBC1D3 oncoprotein enhances growth factor receptor signaling and subsequently promotes cellular proliferation and survival. Here we report that TBC1D3 is degraded in response to growth factor signaling, suggesting that TBC1D3 expression is regulated by a growth fa...

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Detalles Bibliográficos
Autores principales: Kong, Chen, Samovski, Dmitri, Srikanth, Priya, Wainszelbaum, Marisa J., Charron, Audra J., Liu, Jialiu, Lange, Jeffrey J., Chen, Pin-I, Pan, Zhen-Qiang, Su, Xiong, Stahl, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459922/
https://www.ncbi.nlm.nih.gov/pubmed/23029530
http://dx.doi.org/10.1371/journal.pone.0046485

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