Hypoxia Promotes Osteogenesis but Suppresses Adipogenesis of Human Mesenchymal Stromal Cells in a Hypoxia-Inducible Factor-1 Dependent Manner

BACKGROUND: Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and differentiation of multipotent human mesenchymal stromal cells (hMSC). Therefore, we analyzed the impact of hypoxia...

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Detalles Bibliográficos
Autores principales: Wagegg, Markus, Gaber, Timo, Lohanatha, Ferenz L., Hahne, Martin, Strehl, Cindy, Fangradt, Monique, Tran, Cam Loan, Schönbeck, Kerstin, Hoff, Paula, Ode, Andrea, Perka, Carsten, Duda, Georg N., Buttgereit, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459928/
https://www.ncbi.nlm.nih.gov/pubmed/23029528
http://dx.doi.org/10.1371/journal.pone.0046483

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