Genomic instability at the 13q31 locus and somatic mtDNA mutation in the D-loop site correlate with tumor aggressiveness in sporadic Brazilian breast cancer cases

OBJECTIVE: Genomic instability is a hallmark of malignant tissues. In this work, we aimed to characterize nuclear and mitochondrial instabilities by determining short tandem repeats and somatic mitochondrial mutations, respectively, in a cohort of Brazilian sporadic breast cancer cases. Furthermore,...

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Detalles Bibliográficos
Autores principales: dos Santos, Gilson Costa, de Souza Góes, Andréa Carla, de Vitto, Humberto, Moreira, Carla Cristina, Avvad, Elizabeth, Rumjanek, Franklin David, de Moura Gallo, Claudia Vitoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460021/
https://www.ncbi.nlm.nih.gov/pubmed/23070345
http://dx.doi.org/10.6061/clinics/2012(10)10

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