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Therapeutic approaches for spinal cord injury

This study reviews the literature concerning possible therapeutic approaches for spinal cord injury. Spinal cord injury is a disabling and irreversible condition that has high economic and social costs. There are both primary and secondary mechanisms of damage to the spinal cord. The primary lesion...

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Autores principales: Cristante, Alexandre Fogaça, de Barros Filho, Tarcísio Eloy Pessoa, Marcon, Raphael Martus, Letaif, Olavo Biraghi, da Rocha, Ivan Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460027/
https://www.ncbi.nlm.nih.gov/pubmed/23070351
http://dx.doi.org/10.6061/clinics/2012(10)16
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author Cristante, Alexandre Fogaça
de Barros Filho, Tarcísio Eloy Pessoa
Marcon, Raphael Martus
Letaif, Olavo Biraghi
da Rocha, Ivan Dias
author_facet Cristante, Alexandre Fogaça
de Barros Filho, Tarcísio Eloy Pessoa
Marcon, Raphael Martus
Letaif, Olavo Biraghi
da Rocha, Ivan Dias
author_sort Cristante, Alexandre Fogaça
collection PubMed
description This study reviews the literature concerning possible therapeutic approaches for spinal cord injury. Spinal cord injury is a disabling and irreversible condition that has high economic and social costs. There are both primary and secondary mechanisms of damage to the spinal cord. The primary lesion is the mechanical injury itself. The secondary lesion results from one or more biochemical and cellular processes that are triggered by the primary lesion. The frustration of health professionals in treating a severe spinal cord injury was described in 1700 BC in an Egyptian surgical papyrus that was translated by Edwin Smith; the papyrus reported spinal fractures as a “disease that should not be treated.” Over the last two decades, several studies have been performed to obtain more effective treatments for spinal cord injury. Most of these studies approach a patient with acute spinal cord injury in one of four manners: corrective surgery or a physical, biological or pharmacological treatment method. Science is unraveling the mechanisms of cell protection and neuroregeneration, but clinically, we only provide supportive care for patients with spinal cord injuries. By combining these treatments, researchers attempt to enhance the functional recovery of patients with spinal cord injuries. Advances in the last decade have allowed us to encourage the development of experimental studies in the field of spinal cord regeneration. The combination of several therapeutic strategies should, at minimum, allow for partial functional recoveries for these patients, which could improve their quality of life.
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spelling pubmed-34600272012-10-01 Therapeutic approaches for spinal cord injury Cristante, Alexandre Fogaça de Barros Filho, Tarcísio Eloy Pessoa Marcon, Raphael Martus Letaif, Olavo Biraghi da Rocha, Ivan Dias Clinics (Sao Paulo) Review This study reviews the literature concerning possible therapeutic approaches for spinal cord injury. Spinal cord injury is a disabling and irreversible condition that has high economic and social costs. There are both primary and secondary mechanisms of damage to the spinal cord. The primary lesion is the mechanical injury itself. The secondary lesion results from one or more biochemical and cellular processes that are triggered by the primary lesion. The frustration of health professionals in treating a severe spinal cord injury was described in 1700 BC in an Egyptian surgical papyrus that was translated by Edwin Smith; the papyrus reported spinal fractures as a “disease that should not be treated.” Over the last two decades, several studies have been performed to obtain more effective treatments for spinal cord injury. Most of these studies approach a patient with acute spinal cord injury in one of four manners: corrective surgery or a physical, biological or pharmacological treatment method. Science is unraveling the mechanisms of cell protection and neuroregeneration, but clinically, we only provide supportive care for patients with spinal cord injuries. By combining these treatments, researchers attempt to enhance the functional recovery of patients with spinal cord injuries. Advances in the last decade have allowed us to encourage the development of experimental studies in the field of spinal cord regeneration. The combination of several therapeutic strategies should, at minimum, allow for partial functional recoveries for these patients, which could improve their quality of life. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2012-10 /pmc/articles/PMC3460027/ /pubmed/23070351 http://dx.doi.org/10.6061/clinics/2012(10)16 Text en Copyright © 2012 Hospital das Clínicas da FMUSP http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Cristante, Alexandre Fogaça
de Barros Filho, Tarcísio Eloy Pessoa
Marcon, Raphael Martus
Letaif, Olavo Biraghi
da Rocha, Ivan Dias
Therapeutic approaches for spinal cord injury
title Therapeutic approaches for spinal cord injury
title_full Therapeutic approaches for spinal cord injury
title_fullStr Therapeutic approaches for spinal cord injury
title_full_unstemmed Therapeutic approaches for spinal cord injury
title_short Therapeutic approaches for spinal cord injury
title_sort therapeutic approaches for spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460027/
https://www.ncbi.nlm.nih.gov/pubmed/23070351
http://dx.doi.org/10.6061/clinics/2012(10)16
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