[(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches

Changes in the expression of the melanin concentrating hormone receptor 1 (MCHR1) are involved in a variety of pathologies, especially obesity and anxiety disorders. To monitor these pathologies in-vivo positron emission tomography (PET) is a suitable method. After the successful radiosynthesis of [...

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Autores principales: Philippe, Cécile, Ungersboeck, Johanna, Schirmer, Eva, Zdravkovic, Milica, Nics, Lukas, Zeilinger, Markus, Shanab, Karem, Lanzenberger, Rupert, Karanikas, Georgios, Spreitzer, Helmut, Viernstein, Helmut, Mitterhauser, Markus, Wadsak, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460236/
https://www.ncbi.nlm.nih.gov/pubmed/22921745
http://dx.doi.org/10.1016/j.bmc.2012.07.051
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author Philippe, Cécile
Ungersboeck, Johanna
Schirmer, Eva
Zdravkovic, Milica
Nics, Lukas
Zeilinger, Markus
Shanab, Karem
Lanzenberger, Rupert
Karanikas, Georgios
Spreitzer, Helmut
Viernstein, Helmut
Mitterhauser, Markus
Wadsak, Wolfgang
author_facet Philippe, Cécile
Ungersboeck, Johanna
Schirmer, Eva
Zdravkovic, Milica
Nics, Lukas
Zeilinger, Markus
Shanab, Karem
Lanzenberger, Rupert
Karanikas, Georgios
Spreitzer, Helmut
Viernstein, Helmut
Mitterhauser, Markus
Wadsak, Wolfgang
author_sort Philippe, Cécile
collection PubMed
description Changes in the expression of the melanin concentrating hormone receptor 1 (MCHR1) are involved in a variety of pathologies, especially obesity and anxiety disorders. To monitor these pathologies in-vivo positron emission tomography (PET) is a suitable method. After the successful radiosynthesis of [(11)C]SNAP-7941—the first PET-Tracer for the MCHR1, we aimed to synthesize its [(18)F]fluoroethylated analogue: [(18)F]FE@SNAP. Therefore, microfluidic and vessel-based approaches were tested. [(18)F]fluoroethylation was conducted via various [(18)F]fluoroalkylated synthons and direct [(18)F]fluorination. Only the direct [(18)F]fluorination of a tosylated precursor using a flow-through microreactor was successful, affording [(18)F]FE@SNAP in 44.3 ± 2.6%.
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spelling pubmed-34602362012-10-16 [(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches Philippe, Cécile Ungersboeck, Johanna Schirmer, Eva Zdravkovic, Milica Nics, Lukas Zeilinger, Markus Shanab, Karem Lanzenberger, Rupert Karanikas, Georgios Spreitzer, Helmut Viernstein, Helmut Mitterhauser, Markus Wadsak, Wolfgang Bioorg Med Chem Article Changes in the expression of the melanin concentrating hormone receptor 1 (MCHR1) are involved in a variety of pathologies, especially obesity and anxiety disorders. To monitor these pathologies in-vivo positron emission tomography (PET) is a suitable method. After the successful radiosynthesis of [(11)C]SNAP-7941—the first PET-Tracer for the MCHR1, we aimed to synthesize its [(18)F]fluoroethylated analogue: [(18)F]FE@SNAP. Therefore, microfluidic and vessel-based approaches were tested. [(18)F]fluoroethylation was conducted via various [(18)F]fluoroalkylated synthons and direct [(18)F]fluorination. Only the direct [(18)F]fluorination of a tosylated precursor using a flow-through microreactor was successful, affording [(18)F]FE@SNAP in 44.3 ± 2.6%. Elsevier Science 2012-10-01 /pmc/articles/PMC3460236/ /pubmed/22921745 http://dx.doi.org/10.1016/j.bmc.2012.07.051 Text en © 2012 Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Article
Philippe, Cécile
Ungersboeck, Johanna
Schirmer, Eva
Zdravkovic, Milica
Nics, Lukas
Zeilinger, Markus
Shanab, Karem
Lanzenberger, Rupert
Karanikas, Georgios
Spreitzer, Helmut
Viernstein, Helmut
Mitterhauser, Markus
Wadsak, Wolfgang
[(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
title [(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
title_full [(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
title_fullStr [(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
title_full_unstemmed [(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
title_short [(18)F]FE@SNAP—A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches
title_sort [(18)f]fe@snap—a new pet tracer for the melanin concentrating hormone receptor 1 (mchr1): microfluidic and vessel-based approaches
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460236/
https://www.ncbi.nlm.nih.gov/pubmed/22921745
http://dx.doi.org/10.1016/j.bmc.2012.07.051
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