JAK Kinases in Health and Disease: An Update

Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the pale...

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Detalles Bibliográficos
Autores principales: Laurence, Arian, Pesu, Marko, Silvennoinen, Olli, O’Shea, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460320/
https://www.ncbi.nlm.nih.gov/pubmed/23028408
http://dx.doi.org/10.2174/1874312901206010232
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author Laurence, Arian
Pesu, Marko
Silvennoinen, Olli
O’Shea, John
author_facet Laurence, Arian
Pesu, Marko
Silvennoinen, Olli
O’Shea, John
author_sort Laurence, Arian
collection PubMed
description Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.
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spelling pubmed-34603202012-10-01 JAK Kinases in Health and Disease: An Update Laurence, Arian Pesu, Marko Silvennoinen, Olli O’Shea, John Open Rheumatol J Article Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors. Bentham Open 2012-09-07 /pmc/articles/PMC3460320/ /pubmed/23028408 http://dx.doi.org/10.2174/1874312901206010232 Text en © Laurence et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Laurence, Arian
Pesu, Marko
Silvennoinen, Olli
O’Shea, John
JAK Kinases in Health and Disease: An Update
title JAK Kinases in Health and Disease: An Update
title_full JAK Kinases in Health and Disease: An Update
title_fullStr JAK Kinases in Health and Disease: An Update
title_full_unstemmed JAK Kinases in Health and Disease: An Update
title_short JAK Kinases in Health and Disease: An Update
title_sort jak kinases in health and disease: an update
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460320/
https://www.ncbi.nlm.nih.gov/pubmed/23028408
http://dx.doi.org/10.2174/1874312901206010232
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