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HIV infection and stroke: current perspectives and future directions
HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. However, the occurrence of stroke and HIV infection might often be coincidental. HIV-associated vasculopathy describes various cerebrovascular changes, includ...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lancet Pub. Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460367/ https://www.ncbi.nlm.nih.gov/pubmed/22995692 http://dx.doi.org/10.1016/S1474-4422(12)70205-3 |
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author | Benjamin, Laura A Bryer, Alan Emsley, Hedley CA Khoo, Saye Solomon, Tom Connor, Myles D |
author_facet | Benjamin, Laura A Bryer, Alan Emsley, Hedley CA Khoo, Saye Solomon, Tom Connor, Myles D |
author_sort | Benjamin, Laura A |
collection | PubMed |
description | HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. However, the occurrence of stroke and HIV infection might often be coincidental. HIV-associated vasculopathy describes various cerebrovascular changes, including stenosis and aneurysm formation, vasculitis, and accelerated atherosclerosis, and might be caused directly or indirectly by HIV infection, although the mechanisms are controversial. HIV and associated infections contribute to chronic inflammation. Combination antiretroviral therapies (cART) are clearly beneficial, but can be atherogenic and could increase stroke risk. cART can prolong life, increasing the size of the ageing population at risk of stroke. Stroke management and prevention should include identification and treatment of the specific cause of stroke and stroke risk factors, and judicious adjustment of the cART regimen. Epidemiological, clinical, biological, and autopsy studies of risk, the pathogenesis of HIV-associated vasculopathy (particularly of arterial endothelial damage), the long-term effects of cART, and ideal stroke treatment in patients with HIV are needed, as are antiretrovirals that are without vascular risk. |
format | Online Article Text |
id | pubmed-3460367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Lancet Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-34603672012-10-16 HIV infection and stroke: current perspectives and future directions Benjamin, Laura A Bryer, Alan Emsley, Hedley CA Khoo, Saye Solomon, Tom Connor, Myles D Lancet Neurol Review HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. However, the occurrence of stroke and HIV infection might often be coincidental. HIV-associated vasculopathy describes various cerebrovascular changes, including stenosis and aneurysm formation, vasculitis, and accelerated atherosclerosis, and might be caused directly or indirectly by HIV infection, although the mechanisms are controversial. HIV and associated infections contribute to chronic inflammation. Combination antiretroviral therapies (cART) are clearly beneficial, but can be atherogenic and could increase stroke risk. cART can prolong life, increasing the size of the ageing population at risk of stroke. Stroke management and prevention should include identification and treatment of the specific cause of stroke and stroke risk factors, and judicious adjustment of the cART regimen. Epidemiological, clinical, biological, and autopsy studies of risk, the pathogenesis of HIV-associated vasculopathy (particularly of arterial endothelial damage), the long-term effects of cART, and ideal stroke treatment in patients with HIV are needed, as are antiretrovirals that are without vascular risk. Lancet Pub. Group 2012-10 /pmc/articles/PMC3460367/ /pubmed/22995692 http://dx.doi.org/10.1016/S1474-4422(12)70205-3 Text en © 2012 Elsevier Ltd. All rights reserved. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Review Benjamin, Laura A Bryer, Alan Emsley, Hedley CA Khoo, Saye Solomon, Tom Connor, Myles D HIV infection and stroke: current perspectives and future directions |
title | HIV infection and stroke: current perspectives and future directions |
title_full | HIV infection and stroke: current perspectives and future directions |
title_fullStr | HIV infection and stroke: current perspectives and future directions |
title_full_unstemmed | HIV infection and stroke: current perspectives and future directions |
title_short | HIV infection and stroke: current perspectives and future directions |
title_sort | hiv infection and stroke: current perspectives and future directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460367/ https://www.ncbi.nlm.nih.gov/pubmed/22995692 http://dx.doi.org/10.1016/S1474-4422(12)70205-3 |
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