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HIV infection and stroke: current perspectives and future directions

HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. However, the occurrence of stroke and HIV infection might often be coincidental. HIV-associated vasculopathy describes various cerebrovascular changes, includ...

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Autores principales: Benjamin, Laura A, Bryer, Alan, Emsley, Hedley CA, Khoo, Saye, Solomon, Tom, Connor, Myles D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lancet Pub. Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460367/
https://www.ncbi.nlm.nih.gov/pubmed/22995692
http://dx.doi.org/10.1016/S1474-4422(12)70205-3
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author Benjamin, Laura A
Bryer, Alan
Emsley, Hedley CA
Khoo, Saye
Solomon, Tom
Connor, Myles D
author_facet Benjamin, Laura A
Bryer, Alan
Emsley, Hedley CA
Khoo, Saye
Solomon, Tom
Connor, Myles D
author_sort Benjamin, Laura A
collection PubMed
description HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. However, the occurrence of stroke and HIV infection might often be coincidental. HIV-associated vasculopathy describes various cerebrovascular changes, including stenosis and aneurysm formation, vasculitis, and accelerated atherosclerosis, and might be caused directly or indirectly by HIV infection, although the mechanisms are controversial. HIV and associated infections contribute to chronic inflammation. Combination antiretroviral therapies (cART) are clearly beneficial, but can be atherogenic and could increase stroke risk. cART can prolong life, increasing the size of the ageing population at risk of stroke. Stroke management and prevention should include identification and treatment of the specific cause of stroke and stroke risk factors, and judicious adjustment of the cART regimen. Epidemiological, clinical, biological, and autopsy studies of risk, the pathogenesis of HIV-associated vasculopathy (particularly of arterial endothelial damage), the long-term effects of cART, and ideal stroke treatment in patients with HIV are needed, as are antiretrovirals that are without vascular risk.
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spelling pubmed-34603672012-10-16 HIV infection and stroke: current perspectives and future directions Benjamin, Laura A Bryer, Alan Emsley, Hedley CA Khoo, Saye Solomon, Tom Connor, Myles D Lancet Neurol Review HIV infection can result in stroke via several mechanisms, including opportunistic infection, vasculopathy, cardioembolism, and coagulopathy. However, the occurrence of stroke and HIV infection might often be coincidental. HIV-associated vasculopathy describes various cerebrovascular changes, including stenosis and aneurysm formation, vasculitis, and accelerated atherosclerosis, and might be caused directly or indirectly by HIV infection, although the mechanisms are controversial. HIV and associated infections contribute to chronic inflammation. Combination antiretroviral therapies (cART) are clearly beneficial, but can be atherogenic and could increase stroke risk. cART can prolong life, increasing the size of the ageing population at risk of stroke. Stroke management and prevention should include identification and treatment of the specific cause of stroke and stroke risk factors, and judicious adjustment of the cART regimen. Epidemiological, clinical, biological, and autopsy studies of risk, the pathogenesis of HIV-associated vasculopathy (particularly of arterial endothelial damage), the long-term effects of cART, and ideal stroke treatment in patients with HIV are needed, as are antiretrovirals that are without vascular risk. Lancet Pub. Group 2012-10 /pmc/articles/PMC3460367/ /pubmed/22995692 http://dx.doi.org/10.1016/S1474-4422(12)70205-3 Text en © 2012 Elsevier Ltd. All rights reserved. https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Review
Benjamin, Laura A
Bryer, Alan
Emsley, Hedley CA
Khoo, Saye
Solomon, Tom
Connor, Myles D
HIV infection and stroke: current perspectives and future directions
title HIV infection and stroke: current perspectives and future directions
title_full HIV infection and stroke: current perspectives and future directions
title_fullStr HIV infection and stroke: current perspectives and future directions
title_full_unstemmed HIV infection and stroke: current perspectives and future directions
title_short HIV infection and stroke: current perspectives and future directions
title_sort hiv infection and stroke: current perspectives and future directions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460367/
https://www.ncbi.nlm.nih.gov/pubmed/22995692
http://dx.doi.org/10.1016/S1474-4422(12)70205-3
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