Cargando…

Calcium Currents Are Enhanced by α(2)δ-1 Lacking Its Membrane Anchor

The accessory α(2)δ subunits of voltage-gated calcium channels are membrane-anchored proteins, which are highly glycosylated, possess multiple disulfide bonds, and are post-translationally cleaved into α(2) and δ. All α(2)δ subunits have a C-terminal hydrophobic, potentially trans-membrane domain an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kadurin, Ivan, Alvarez-Laviada, Anita, Ng, Shu Fun Josephine, Walker-Gray, Ryan, D'Arco, Marianna, Fadel, Michael G., Pratt, Wendy S., Dolphin, Annette C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Neurobiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460456/ https://www.ncbi.nlm.nih.gov/pubmed/22869375 http://dx.doi.org/10.1074/jbc.M112.378554

Ejemplares similares

The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α(2)δ for GPI-anchoring pathways
por: Alvarez-Laviada, Anita, et al.
Publicado: (2014)

The Ca(V)β Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel Ca(V)2.2 from Proteasomal Degradation but Not Oligoubiquitination
por: Page, Karen M., et al.
Publicado: (2016)

β-Subunits Promote the Expression of Ca(V)2.2 Channels by Reducing Their Proteasomal Degradation
por: Waithe, Dominic, et al.
Publicado: (2011)

Calmodulin regulates Ca(v)3 T-type channels at their gating brake
por: Chemin, Jean, et al.
Publicado: (2017)

Loading a Calcium Dye into Frog Nerve Endings Through the Nerve Stump: Calcium Transient Registration in the Frog Neuromuscular Junction
por: Samigullin, Dmitry V., et al.
Publicado: (2017)

The α(2)δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α(2)δ-1
por: Dahimene, Shehrazade, et al.
Publicado: (2018)

Mitochondrial Calcium Uptake Modulates Synaptic Vesicle Endocytosis in Central Nerve Terminals
por: Marland, Jamie Roslin Keynes, et al.
Publicado: (2016)

Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway
por: Yao, Jin-jing, et al.
Publicado: (2016)

Proteolytic maturation of α(2)δ controls the probability of synaptic vesicular release
por: Ferron, Laurent, et al.
Publicado: (2018)

A Ca(V)2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant
por: Dahimene, Shehrazade, et al.
Publicado: (2016)

Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic Neurodegeneration
por: Asuni, Ayodeji A., et al.
Publicado: (2014)

LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α(2)δ-1 subunit
por: Kadurin, Ivan, et al.
Publicado: (2017)

Proteolytic maturation of α(2)δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels
por: Kadurin, Ivan, et al.
Publicado: (2016)

Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α(2)δ-1-subunit but does not interact with α(2)δ-1 on the cell-surface when co-expressed
por: Lana, Beatrice, et al.
Publicado: (2016)

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α(2)δ Subunits, and Enables Calcium Current Enhancement
por: Kadurin, Ivan, et al.
Publicado: (2022)

Spatial facilitation by a high-performance dragonfly target-detecting neuron
por: Nordström, Karin, et al.
Publicado: (2011)

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses
por: Verpelli, Chiara, et al.
Publicado: (2011)

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation
por: Zucchelli, Silvia, et al.
Publicado: (2011)

Differentiation of Embryonic Stem Cells into Oligodendrocyte Precursors
por: Jiang, Peng, et al.
Publicado: (2010)

Aph-1 Associates Directly with Full-length and C-terminal Fragments of γ-Secretase Substrates
por: Chen, Allen C., et al.
Publicado: (2010)

The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines
por: Sucic, Sonja, et al.
Publicado: (2010)

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo
por: Lou, Haiyan, et al.
Publicado: (2010)

The Longin SNARE VAMP7/TI-VAMP Adopts a Closed Conformation
por: Vivona, Sandro, et al.
Publicado: (2010)

High Affinity Neurexin Binding to Cell Adhesion G-protein-coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex
por: Boucard, Antony A., et al.
Publicado: (2012)

Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation
por: Ding, Yun, et al.
Publicado: (2012)

20-Hydroxyeicosatetraenoic Acid (20-HETE) Is a Novel Activator of Transient Receptor Potential Vanilloid 1 (TRPV1) Channel
por: Wen, Hairuo, et al.
Publicado: (2012)

Allele-specific Differences in Activity of a Novel Cannabinoid Receptor 1 (CNR1) Gene Intronic Enhancer in Hypothalamus, Dorsal Root Ganglia, and Hippocampus
por: Nicoll, Gemma, et al.
Publicado: (2012)

Krüppel-like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells
por: Seo, Seungmae, et al.
Publicado: (2012)

Vertebrate ancient opsin photopigment spectra and the avian photoperiodic response
por: Davies, Wayne I. L., et al.
Publicado: (2012)

Extrasynaptic N-Methyl-d-aspartate (NMDA) Receptor Stimulation Induces Cytoplasmic Translocation of the CDKL5 Kinase and Its Proteasomal Degradation
por: Rusconi, Laura, et al.
Publicado: (2011)

Alternative Splicing Modulates Inactivation of Type 1 Voltage-gated Sodium Channels by Toggling an Amino Acid in the First S3-S4 Linker
por: Fletcher, Emily V., et al.
Publicado: (2011)

Learning to understand others' actions
por: Press, Clare, et al.
Publicado: (2011)

Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein
por: Boland, Barry, et al.
Publicado: (2010)

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
por: Sephton, Chantelle F., et al.
Publicado: (2011)

Selective prefrontal cortex responses to joint attention in early infancy
por: Grossmann, Tobias, et al.
Publicado: (2010)

P2X7 Receptors Trigger ATP Exocytosis and Modify Secretory Vesicle Dynamics in Neuroblastoma Cells
por: Gutiérrez-Martín, Yolanda, et al.
Publicado: (2011)

Dopamine Transporter Phosphorylation Site Threonine 53 Regulates Substrate Reuptake and Amphetamine-stimulated Efflux
por: Foster, James D., et al.
Publicado: (2012)

Ca(2+)/Calmodulin-dependent Protein Kinase IIα (αCaMKII) Controls the Activity of the Dopamine Transporter: IMPLICATIONS FOR ANGELMAN SYNDROME
por: Steinkellner, Thomas, et al.
Publicado: (2012)

Proteomic Analysis of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor Complexes
por: Kang, Myoung-Goo, et al.
Publicado: (2012)

Formyl Peptide Receptors from Immune and Vomeronasal System Exhibit Distinct Agonist Properties
por: Bufe, Bernd, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_bcj919h4is6ohm4j0ufjf6mshu