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TLR signaling augments macrophage bactericidal activity through mitochondrial ROS

Reactive oxygen species (ROS) are essential components of the innate immune response against intracellular bacteria, and it is thought that professional phagocytes generate ROS primarily via the phagosomal NADPH oxidase (Phox) machinery(1). However, recent studies have suggested that mitochondrial R...

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Detalles Bibliográficos
Autores principales:	West, A. Phillip, Brodsky, Igor E., Rahner, Christoph, Woo, Dong Kyun, Erdjument-Bromage, Hediye, Tempst, Paul, Walsh, Matthew C., Choi, Yongwon, Shadel, Gerald S., Ghosh, Sankar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460538/ https://www.ncbi.nlm.nih.gov/pubmed/21525932 http://dx.doi.org/10.1038/nature09973

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