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Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling Activities

Tetherin (BST-2/CD317/HM1.24) is an IFN induced transmembrane protein that restricts release of a broad range of enveloped viruses. Important features required for Tetherin activity and regulation reside within the cytoplasmic domain. Here we demonstrate that two isoforms, derived by alternative tra...

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Detalles Bibliográficos
Autores principales: Cocka, Luis J., Bates, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460627/
https://www.ncbi.nlm.nih.gov/pubmed/23028328
http://dx.doi.org/10.1371/journal.ppat.1002931