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Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression
The urgent requirement of next generation antimalarials has been of recent interest due to the emergence of drug-resistant parasite. The genome-wide analysis of Plasmodium falciparum helicases revealed three RuvB proteins. Due to the presence of helicase motif I and II in PfRuvBs, there is a high pr...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460840/ https://www.ncbi.nlm.nih.gov/pubmed/23060959 http://dx.doi.org/10.4161/cib.20005 |
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author | Ahmad, Moaz Tuteja, Renu |
author_facet | Ahmad, Moaz Tuteja, Renu |
author_sort | Ahmad, Moaz |
collection | PubMed |
description | The urgent requirement of next generation antimalarials has been of recent interest due to the emergence of drug-resistant parasite. The genome-wide analysis of Plasmodium falciparum helicases revealed three RuvB proteins. Due to the presence of helicase motif I and II in PfRuvBs, there is a high probability that they contain ATPase and possibly helicase activity. The Plasmodium database has homologs of several key proteins that interact with RuvBs and are most likely involved in the cell cycle progression, chromatin remodeling, and other cellular activities. Phylogenetically PfRuvBs are closely related to Saccharomyces cerevisiae RuvB, which is essential for cell cycle progression and survival of yeast. Thus PfRuvBs can serve as potential drug target if they show an essential role in the survival of parasite. |
format | Online Article Text |
id | pubmed-3460840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-34608402012-10-11 Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression Ahmad, Moaz Tuteja, Renu Commun Integr Biol Review The urgent requirement of next generation antimalarials has been of recent interest due to the emergence of drug-resistant parasite. The genome-wide analysis of Plasmodium falciparum helicases revealed three RuvB proteins. Due to the presence of helicase motif I and II in PfRuvBs, there is a high probability that they contain ATPase and possibly helicase activity. The Plasmodium database has homologs of several key proteins that interact with RuvBs and are most likely involved in the cell cycle progression, chromatin remodeling, and other cellular activities. Phylogenetically PfRuvBs are closely related to Saccharomyces cerevisiae RuvB, which is essential for cell cycle progression and survival of yeast. Thus PfRuvBs can serve as potential drug target if they show an essential role in the survival of parasite. Landes Bioscience 2012-07-01 /pmc/articles/PMC3460840/ /pubmed/23060959 http://dx.doi.org/10.4161/cib.20005 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Ahmad, Moaz Tuteja, Renu Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression |
title | Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression |
title_full | Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression |
title_fullStr | Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression |
title_full_unstemmed | Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression |
title_short | Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression |
title_sort | plasmodium falciparum ruvb proteins: emerging importance and expectations beyond cell cycle progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460840/ https://www.ncbi.nlm.nih.gov/pubmed/23060959 http://dx.doi.org/10.4161/cib.20005 |
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