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How do T-type calcium channels control low-threshold exocytosis?

Low-voltage-activated T-type calcium channels act as a major pathway for calcium entry near the resting membrane potential in a wide range of neuronal cell types. Several reports have uncovered an unrecognized feature of T-type channels in the control of vesicular neurotransmitter and hormone releas...

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Detalles Bibliográficos
Autores principales: Weiss, Norbert, Zamponi, Gerald W., De Waard, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460844/
https://www.ncbi.nlm.nih.gov/pubmed/23060963
http://dx.doi.org/10.4161/cib.19997
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author Weiss, Norbert
Zamponi, Gerald W.
De Waard, Michel
author_facet Weiss, Norbert
Zamponi, Gerald W.
De Waard, Michel
author_sort Weiss, Norbert
collection PubMed
description Low-voltage-activated T-type calcium channels act as a major pathway for calcium entry near the resting membrane potential in a wide range of neuronal cell types. Several reports have uncovered an unrecognized feature of T-type channels in the control of vesicular neurotransmitter and hormone release, a process so far thought to be mediated exclusively by high-voltage-activated calcium channels. However, the underlying molecular mechanisms linking T-type calcium channels to vesicular exocytosis have remained enigmatic. In a recent study, we have reported that Ca(v)3.2 T-type channel forms a signaling complex with the neuronal Q-SNARE syntaxin-1A and SNAP-25. This interaction that relies on specific Ca(v)3.2 molecular determinants, not only modulates T-type channel activity, but was also found essential to support low-threshold exocytosis upon Ca(v)3.2 channel expression in MPC 9/3L-AH chromaffin cells. Overall, we have indentified an unrecognized regulation pathway of T-type calcium channels by SNARE proteins, and proposed the first molecular mechanism by which T-type channels could mediate low-threshold exocytosis.
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spelling pubmed-34608442012-10-11 How do T-type calcium channels control low-threshold exocytosis? Weiss, Norbert Zamponi, Gerald W. De Waard, Michel Commun Integr Biol Article Addendum Low-voltage-activated T-type calcium channels act as a major pathway for calcium entry near the resting membrane potential in a wide range of neuronal cell types. Several reports have uncovered an unrecognized feature of T-type channels in the control of vesicular neurotransmitter and hormone release, a process so far thought to be mediated exclusively by high-voltage-activated calcium channels. However, the underlying molecular mechanisms linking T-type calcium channels to vesicular exocytosis have remained enigmatic. In a recent study, we have reported that Ca(v)3.2 T-type channel forms a signaling complex with the neuronal Q-SNARE syntaxin-1A and SNAP-25. This interaction that relies on specific Ca(v)3.2 molecular determinants, not only modulates T-type channel activity, but was also found essential to support low-threshold exocytosis upon Ca(v)3.2 channel expression in MPC 9/3L-AH chromaffin cells. Overall, we have indentified an unrecognized regulation pathway of T-type calcium channels by SNARE proteins, and proposed the first molecular mechanism by which T-type channels could mediate low-threshold exocytosis. Landes Bioscience 2012-07-01 /pmc/articles/PMC3460844/ /pubmed/23060963 http://dx.doi.org/10.4161/cib.19997 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Article Addendum
Weiss, Norbert
Zamponi, Gerald W.
De Waard, Michel
How do T-type calcium channels control low-threshold exocytosis?
title How do T-type calcium channels control low-threshold exocytosis?
title_full How do T-type calcium channels control low-threshold exocytosis?
title_fullStr How do T-type calcium channels control low-threshold exocytosis?
title_full_unstemmed How do T-type calcium channels control low-threshold exocytosis?
title_short How do T-type calcium channels control low-threshold exocytosis?
title_sort how do t-type calcium channels control low-threshold exocytosis?
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460844/
https://www.ncbi.nlm.nih.gov/pubmed/23060963
http://dx.doi.org/10.4161/cib.19997
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