Cargando…

Checkpoint Kinase ATR Phosphorylates Cdt2, a Substrate Receptor of CRL4 Ubiquitin Ligase, and Promotes the Degradation of Cdt1 following UV Irradiation

The DNA replication-licensing factor Cdt1 is present during the G1 phase of the cell cycle. When cells initiate S phase or are UV-irradiated, Cdt1 is recruited to chromatin-bound PCNA and ubiquitinated by CRL4(Cdt2) for degradation. In both situations, the substrate-recognizing subunit Cdt2 is detec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakaguchi, Hiroki, Takami, Toshihiro, Yasutani, Yoshinori, Maeda, Takeshi, Morino, Masayuki, Ishii, Takashi, Shiomi, Yasushi, Nishitani, Hideo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460910/ https://www.ncbi.nlm.nih.gov/pubmed/23029527 http://dx.doi.org/10.1371/journal.pone.0046480

Ejemplares similares

Direct binding of Cdt2 to PCNA is important for targeting the CRL4(Cdt2) E3 ligase activity to Cdt1
por: Hayashi, Akiyo, et al.
Publicado: (2018)

CRL4(Cdt2) Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA
por: Mazian, Muadz Ahmad, et al.
Publicado: (2022)

The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase
por: Olivero, Martina, et al.
Publicado: (2014)

CRL4(Cdt2) ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation
por: Zhang, Jia-Min, et al.
Publicado: (2020)

Control of Drosophila endocycles by E2F and CRL4(Cdt2)
por: Zielke, Norman, et al.
Publicado: (2011)

SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
por: Jørgensen, Stine, et al.
Publicado: (2011)

Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs
por: Stathopoulou, Athanasia, et al.
Publicado: (2012)

The caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells
por: Poulin, Gino B, et al.
Publicado: (2010)

Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins
por: Dixon, Shandee D., et al.
Publicado: (2015)

Mitotic UV Irradiation Induces a DNA Replication-Licensing Defect that Potentiates G1 Arrest Response
por: Morino, Masayuki, et al.
Publicado: (2015)

Characteristics of the new phase in CDT
por: Ambjørn, J., et al.
Publicado: (2017)

PIP degron proteins, substrates of CRL4(Cdt2), and not PIP boxes, interfere with DNA polymerase η and κ focus formation on UV damage
por: Tsanov, Nikolay, et al.
Publicado: (2014)

The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells
por: Bacquin, Agathe, et al.
Publicado: (2013)

Impact of CDT Toxin on Human Diseases
por: Faïs, Tiphanie, et al.
Publicado: (2016)

The Distribution of Cytotoxic Necrotizing Factors (CNF-1, CNF-2, CNF-3) and Cytolethal Distending Toxins (CDT-1, CDT-2, CDT-3, CDT-4) in Escherichia coli Isolates Isolated from Extraintestinal Infections and the Determination of their Phylogenetic Relationship by PFGE
por: Onlen Guneri, Cansu, et al.
Publicado: (2022)

An Inactive Geminin Mutant That Binds Cdt1
por: Suchyta, Marissa, et al.
Publicado: (2015)

Phosphorylation and functionality of CdtR in Clostridium difficile
por: Bilverstone, T.W., et al.
Publicado: (2019)

Efficient Parvovirus Replication Requires CRL4(Cdt2)-Targeted Depletion of p21 to Prevent Its Inhibitory Interaction with PCNA
por: Adeyemi, Richard O., et al.
Publicado: (2014)

Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma
por: Benamar, Mouadh, et al.
Publicado: (2016)

CRL Ubiquitin Ligases and DNA Damage Response
por: Li, Ju-Mei, et al.
Publicado: (2012)

Non-Canonical CRL4A/4B(CDT2) Interacts with RAD18 to Modulate Post Replication Repair and Cell Survival
por: Sertic, Sarah, et al.
Publicado: (2013)

Mechanisms of Assembly and Cellular Interactions for the Bacterial Genotoxin CDT
por: Nesic, Dragana, et al.
Publicado: (2005)

Study of the frequency of Clostridium difficile tcdA, tcdB, cdtA and cdtB genes in feces of Calves in south west of Iran
por: Doosti, Abbas, et al.
Publicado: (2014)

Prevalence of binary-toxin genes (cdtA and cdtB) among clinical strains of Clostridium difficile isolated from diarrheal patients in Iran
por: Azimirad, Masoumeh, et al.
Publicado: (2018)

CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1
por: Tong, Xin, et al.
Publicado: (2015)

Functional domains of the Xenopus replication licensing factor Cdt1
por: Ferenbach, Andrew, et al.
Publicado: (2005)

Correction: Mechanisms of Assembly and Cellular Interactions for the Bacterial Genotoxin CDT
por: Nesic, Dragana, et al.
Publicado: (2008)

Alteration of Homeostasis in Pre-osteoclasts Induced by Aggregatibacter actinomycetemcomitans CDT
por: Kawamoto, Dione, et al.
Publicado: (2016)

The prognostic significance of Cdc6 and Cdt1 in breast cancer
por: Mahadevappa, Ravikiran, et al.
Publicado: (2017)

Cdt1 stabilizes an open MCM ring for helicase loading
por: Frigola, Jordi, et al.
Publicado: (2017)

Regulation of DNA Replication Licensing and Re-Replication by Cdt1
por: Zhang, Hui
Publicado: (2021)

Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification
por: Chen, Wenting, et al.
Publicado: (2022)

Development of Clostridium difficile R20291ΔPaLoc model strains and in vitro methodologies reveals CdtR is required for the production of CDT to cytotoxic levels
por: Bilverstone, T.W., et al.
Publicado: (2017)

Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease
por: Lee, Jennifer, et al.
Publicado: (2012)

Stabilisation of half MCM ring by Cdt1 during DNA insertion
por: Guerrero-Puigdevall, Marina, et al.
Publicado: (2021)

CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma
por: Cai, Chenhui, et al.
Publicado: (2021)

Transcriptional Regulation of an Evolutionary Conserved Intergenic Region of CDT2-INTS7
por: Nakagawa, Hiroki, et al.
Publicado: (2008)

Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation
por: Guarino, Estrella, et al.
Publicado: (2011)

Structural insights into the Cdt1-mediated MCM2–7 chromatin loading
por: Liu, Changdong, et al.
Publicado: (2012)

Clostridium difficile binary toxin CDT: Mechanism, epidemiology, and potential clinical importance
por: Gerding, Dale N, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_g14agft42gkn1d2em2a4fcsgba