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Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal

Dysregulation of the sonic hedgehog (Shh) signaling pathway has been associated with cancer stem cells (CSC) and implicated in the initiation of pancreatic cancer. Pancreatic CSCs are rare tumor cells characterized by their ability to self-renew, and are responsible for tumor recurrence accompanied...

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Detalles Bibliográficos
Autores principales:	Rodova, Mariana, Fu, Junsheng, Watkins, Dara Nall, Srivastava, Rakesh K., Shankar, Sharmila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461003/ https://www.ncbi.nlm.nih.gov/pubmed/23029396 http://dx.doi.org/10.1371/journal.pone.0046083

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