Cargando…

Up-Regulation of TIMP-1 by Genipin Inhibits MMP-2 Activities and Suppresses the Metastatic Potential of Human Hepatocellular Carcinoma

AIM OF THE STUDY: Hepatocellular carcinoma is one of the most malignant human cancers with high metastatic potential. The aim of this study is to investigate the anti-metastatic effect of genipin and its underlying mechanism. EXPERIMENTAL APPROACH: The anti-metastatic potential of genipin was evalua...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ning, Zhu, Meifen, Tsao, Sai-Wah, Man, Kwan, Zhang, Zhangjin, Feng, Yibin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461024/ https://www.ncbi.nlm.nih.gov/pubmed/23029478 http://dx.doi.org/10.1371/journal.pone.0046318

Ejemplares similares

MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma
por: Wang, Ning, et al.
Publicado: (2013)

IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma
por: Tan, Hor-Yue, et al.
Publicado: (2016)

Direct inhibition of the TLR4/MyD88 pathway by geniposide suppresses HIF‐1α‐independent VEGF expression and angiogenesis in hepatocellular carcinoma
por: Zhang, Cheng, et al.
Publicado: (2020)

p85α Inactivates MMP-2 and Suppresses Bladder Cancer Invasion by Inhibiting MMP-14 Transcription and TIMP-2 Degradation
por: Wang, Jingjing, et al.
Publicado: (2019)

Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa
por: Mori, Sachiko, et al.
Publicado: (2012)

Expression of the metalloproteases MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas
por: Meneses-García, Abelardo, et al.
Publicado: (2008)

Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction
por: Lu, Xiaofei, et al.
Publicado: (2016)

Genipin-activating PPARγ impedes CCR2-mediated macrophage infiltration into postoperative liver to suppress recurrence of hepatocellular carcinoma
por: Wu, Junyu, et al.
Publicado: (2023)

Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases
por: Jakubowska, Katarzyna, et al.
Publicado: (2016)

MMP-2, MMP-9, TIMP-1, and TIMP-2 in the Peripheral Blood of Patients with Differentiated Thyroid Carcinoma
por: Zhang, Wen-jing, et al.
Publicado: (2019)

The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity
por: Dimic-Janjic, Sanja, et al.
Publicado: (2023)

Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway
por: Kim, Bo Ram, et al.
Publicado: (2017)

MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors
por: Jinga, D C, et al.
Publicado: (2006)

Genipin suppression of growth and metastasis in hepatocellular carcinoma through blocking activation of STAT-3
por: Hong, Ming, et al.
Publicado: (2020)

Diagnostic values of MMP-7, MMP-9, MMP-11, TIMP-1, TIMP-2, CEA, and CA19-9 in patients with colorectal cancer
por: Huang, Xiwen, et al.
Publicado: (2021)

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression
por: Yu, Shui-Xing, et al.
Publicado: (2015)

Plasma Glycosaminoglycan Profiles in Systemic Sclerosis: Associations with MMP-3, MMP-10, TIMP-1, TIMP-2, and TGF-Beta
por: Kuźnik-Trocha, Kornelia, et al.
Publicado: (2020)

TIMP-1, TIMP-2 and MMP-9 as prognostic markers for clinical outcome in sepsis
por: Hoffmann, U, et al.
Publicado: (2003)

Correction: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway
por: Kim, Bo Ram, et al.
Publicado: (2018)

Assessment of RANTES, MIP4A, MMP7, MMP9, MMP14, TIMP 1, TIMP 2 and TIMP 3 concentration in the follicular fluid of patients undergoing in vitro fertilization/embryo transfer procedure
por: Adamczak, Rafał, et al.
Publicado: (2023)

Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell
por: Arkadash, Valeria, et al.
Publicado: (2018)

Upregulation and differential expression of matrilysin (MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett's oesophageal adenocarcinoma
por: Salmela, M T, et al.
Publicado: (2001)

MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models
por: Fioruci-Fontanelli, Beatriz Aparecida, et al.
Publicado: (2015)

The Imbalance of MMP-2/TIMP-2 and MMP-9/TIMP-1 Contributes to Collagen Deposition Disorder in Diabetic Non-Injured Skin
por: Zhou, Peng, et al.
Publicado: (2021)

Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia
por: Forsblom, Erik, et al.
Publicado: (2021)

The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis
por: Łanocha-Arendarczyk, Natalia, et al.
Publicado: (2018)

Mechanisims of asthma and allergic disease – 1077. Differential expression and roles oF MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in allergic rhinitis
por: Mori, Sachiko, et al.
Publicado: (2013)

Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro
por: Dai, Zhi-Jun, et al.
Publicado: (2013)

Genipin inhibits rotavirus-induced diarrhea by suppressing viral replication and regulating inflammatory responses
por: Kim, Jong-Hwa, et al.
Publicado: (2020)

Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells
por: Wang, Ning, et al.
Publicado: (2016)

The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis
por: Têtu, Bernard, et al.
Publicado: (2006)

Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol
por: Balli, Umut, et al.
Publicado: (2016)

Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
por: Vincent, Zoë L, et al.
Publicado: (2015)

Levels of Circulating TIMP-2 and MMP2-TIMP2 Complex Are Decreased in Squamous Cervical Carcinoma
por: Anne, Talvensaari-Mattila, et al.
Publicado: (2010)

Retraction Note: Genipin suppression of growth and metastasis in hepatocellular carcinoma through blocking activation of STAT-3
por: Hong, Ming, et al.
Publicado: (2022)

Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis
por: Azevedo Martins, Jordana Maria, et al.
Publicado: (2020)

Biotransformation of Geniposide into Genipin by Immobilized Trichoderma reesei and Conformational Study of Genipin
por: Yang, Yishun, et al.
Publicado: (2018)

Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer
por: Kubben, F J G M, et al.
Publicado: (2006)

The increased of MMP-9 and MMP-2 with the decreased of TIMP-1 on the uterosacral ligament after childbirth
por: Rahajeng, Rahajeng
Publicado: (2018)

TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9
por: Wang, Weimin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4ae9av0d2td00ujd06c297reqv