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Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population

BACKGROUND: Tissue factor (TF), which has a role in normal tissue haemostasis, was reported to be aberrantly expressed, associated with higher microvascular density and a poor prognosis in intestinal-type gastric adenocarcinoma in the Japanese population. This is the first study to look at the relat...

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Autores principales: Lo, L, Valentine, H, Harrison, J, Hayes, S, Welch, I, Pritchard, S, West, C, Ang, Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461158/
https://www.ncbi.nlm.nih.gov/pubmed/22929889
http://dx.doi.org/10.1038/bjc.2012.363
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author Lo, L
Valentine, H
Harrison, J
Hayes, S
Welch, I
Pritchard, S
West, C
Ang, Y
author_facet Lo, L
Valentine, H
Harrison, J
Hayes, S
Welch, I
Pritchard, S
West, C
Ang, Y
author_sort Lo, L
collection PubMed
description BACKGROUND: Tissue factor (TF), which has a role in normal tissue haemostasis, was reported to be aberrantly expressed, associated with higher microvascular density and a poor prognosis in intestinal-type gastric adenocarcinoma in the Japanese population. This is the first study to look at the relationship of TF and the metaplasia–adenoma–carcinoma sequence (MACS) of gastric cancer in a European population. METHODS: The expression of TF was examined immunohistochemically in 191 gastric tissue samples: (13: normal; 18: intestinal metaplasia; 160: gastric adenocarcinoma) from the European population. RESULTS: TF was not expressed in normal gastric mucosal cells. A strong intensity of staining was found in intestinal metaplasia cells but in 2 of 18 samples. TF expression increased with advancing stage of gastric cancer (P<0.0001, Jonckheere’s test for ordered medians). Stage 3–4 gastric cancers preferentially expressed TF (34%, P=0.04). In comparison with the Japanese study, TF was not expressed at a higher level in intestinal vs diffuse-type gastric cancers and expression had ‘no prognostic’ significance. CONCLUSION: TF may be involved in tumour progression along the MACS of gastric cancer in the European population and is shown to start in precancerous lesions. However, clinical features may differ due to differences in biological features in the two populations, as reflected by differences in TF expression profile.
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spelling pubmed-34611582013-09-25 Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population Lo, L Valentine, H Harrison, J Hayes, S Welch, I Pritchard, S West, C Ang, Y Br J Cancer Molecular Diagnostics BACKGROUND: Tissue factor (TF), which has a role in normal tissue haemostasis, was reported to be aberrantly expressed, associated with higher microvascular density and a poor prognosis in intestinal-type gastric adenocarcinoma in the Japanese population. This is the first study to look at the relationship of TF and the metaplasia–adenoma–carcinoma sequence (MACS) of gastric cancer in a European population. METHODS: The expression of TF was examined immunohistochemically in 191 gastric tissue samples: (13: normal; 18: intestinal metaplasia; 160: gastric adenocarcinoma) from the European population. RESULTS: TF was not expressed in normal gastric mucosal cells. A strong intensity of staining was found in intestinal metaplasia cells but in 2 of 18 samples. TF expression increased with advancing stage of gastric cancer (P<0.0001, Jonckheere’s test for ordered medians). Stage 3–4 gastric cancers preferentially expressed TF (34%, P=0.04). In comparison with the Japanese study, TF was not expressed at a higher level in intestinal vs diffuse-type gastric cancers and expression had ‘no prognostic’ significance. CONCLUSION: TF may be involved in tumour progression along the MACS of gastric cancer in the European population and is shown to start in precancerous lesions. However, clinical features may differ due to differences in biological features in the two populations, as reflected by differences in TF expression profile. Nature Publishing Group 2012-09-25 2012-08-28 /pmc/articles/PMC3461158/ /pubmed/22929889 http://dx.doi.org/10.1038/bjc.2012.363 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by-nc-sa/3.0/From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Molecular Diagnostics
Lo, L
Valentine, H
Harrison, J
Hayes, S
Welch, I
Pritchard, S
West, C
Ang, Y
Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population
title Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population
title_full Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population
title_fullStr Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population
title_full_unstemmed Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population
title_short Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population
title_sort tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a european population
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461158/
https://www.ncbi.nlm.nih.gov/pubmed/22929889
http://dx.doi.org/10.1038/bjc.2012.363
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