Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

Foci of phosphorylated histone H2AX and ATM are the surrogate markers of DNA double strand breaks. We previously reported that the residual foci increased their size after irradiation, which amplifies DNA damage signals. Here, we addressed whether amplification of DNA damage signal is involved in re...

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Detalles Bibliográficos
Autores principales: Suzuki, Masatoshi, Suzuki, Keiji, Kodama, Seiji, Yamashita, Shunichi, Watanabe, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461254/
https://www.ncbi.nlm.nih.gov/pubmed/23050037
http://dx.doi.org/10.1155/2012/310534

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