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Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 case...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461284/ https://www.ncbi.nlm.nih.gov/pubmed/23050156 http://dx.doi.org/10.1155/2012/532547 |
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author | Foster, Matthew R. Harris, Lauren Biesemier, Karl W. |
author_facet | Foster, Matthew R. Harris, Lauren Biesemier, Karl W. |
author_sort | Foster, Matthew R. |
collection | PubMed |
description | Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 cases were examined prospectively over an eight-year period. In 172 cases the sign-out pathologist documented an unexpected finding of potential clinical significance as present only on the large format sections and not present on the accompanying standard format slides. These include closer margins, a change in size or extent of disease, and previously undocumented invasive and/or in situ carcinoma. Based on over a decade of experience and eight years of data, our results demonstrate that a quarter of cases had an unexpected finding of potential clinical significance that may not have been fully realized without the use of the large format technique. |
format | Online Article Text |
id | pubmed-3461284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34612842012-10-04 Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study Foster, Matthew R. Harris, Lauren Biesemier, Karl W. Int J Breast Cancer Clinical Study Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 cases were examined prospectively over an eight-year period. In 172 cases the sign-out pathologist documented an unexpected finding of potential clinical significance as present only on the large format sections and not present on the accompanying standard format slides. These include closer margins, a change in size or extent of disease, and previously undocumented invasive and/or in situ carcinoma. Based on over a decade of experience and eight years of data, our results demonstrate that a quarter of cases had an unexpected finding of potential clinical significance that may not have been fully realized without the use of the large format technique. Hindawi Publishing Corporation 2012 2012-09-20 /pmc/articles/PMC3461284/ /pubmed/23050156 http://dx.doi.org/10.1155/2012/532547 Text en Copyright © 2012 Matthew R. Foster et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Foster, Matthew R. Harris, Lauren Biesemier, Karl W. Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
title | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
title_full | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
title_fullStr | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
title_full_unstemmed | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
title_short | Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study |
title_sort | large format histology may aid in the detection of unsuspected pathologic findings of potential clinical significance: a prospective multiyear single institution study |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461284/ https://www.ncbi.nlm.nih.gov/pubmed/23050156 http://dx.doi.org/10.1155/2012/532547 |
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