Cargando…

Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study

Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 case...

Descripción completa

Detalles Bibliográficos
Autores principales: Foster, Matthew R., Harris, Lauren, Biesemier, Karl W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461284/
https://www.ncbi.nlm.nih.gov/pubmed/23050156
http://dx.doi.org/10.1155/2012/532547
_version_ 1782245057511817216
author Foster, Matthew R.
Harris, Lauren
Biesemier, Karl W.
author_facet Foster, Matthew R.
Harris, Lauren
Biesemier, Karl W.
author_sort Foster, Matthew R.
collection PubMed
description Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 cases were examined prospectively over an eight-year period. In 172 cases the sign-out pathologist documented an unexpected finding of potential clinical significance as present only on the large format sections and not present on the accompanying standard format slides. These include closer margins, a change in size or extent of disease, and previously undocumented invasive and/or in situ carcinoma. Based on over a decade of experience and eight years of data, our results demonstrate that a quarter of cases had an unexpected finding of potential clinical significance that may not have been fully realized without the use of the large format technique.
format Online
Article
Text
id pubmed-3461284
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34612842012-10-04 Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study Foster, Matthew R. Harris, Lauren Biesemier, Karl W. Int J Breast Cancer Clinical Study Large format histology offers several unique advantages over traditional tissue processing. Over 12 years of experience with this technique provide insight into its limitations and benefits. We conducted a prospective multiyear analysis of the potential advantages of large format histology. 656 cases were examined prospectively over an eight-year period. In 172 cases the sign-out pathologist documented an unexpected finding of potential clinical significance as present only on the large format sections and not present on the accompanying standard format slides. These include closer margins, a change in size or extent of disease, and previously undocumented invasive and/or in situ carcinoma. Based on over a decade of experience and eight years of data, our results demonstrate that a quarter of cases had an unexpected finding of potential clinical significance that may not have been fully realized without the use of the large format technique. Hindawi Publishing Corporation 2012 2012-09-20 /pmc/articles/PMC3461284/ /pubmed/23050156 http://dx.doi.org/10.1155/2012/532547 Text en Copyright © 2012 Matthew R. Foster et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Foster, Matthew R.
Harris, Lauren
Biesemier, Karl W.
Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
title Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
title_full Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
title_fullStr Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
title_full_unstemmed Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
title_short Large Format Histology May Aid in the Detection of Unsuspected Pathologic Findings of Potential Clinical Significance: A Prospective Multiyear Single Institution Study
title_sort large format histology may aid in the detection of unsuspected pathologic findings of potential clinical significance: a prospective multiyear single institution study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461284/
https://www.ncbi.nlm.nih.gov/pubmed/23050156
http://dx.doi.org/10.1155/2012/532547
work_keys_str_mv AT fostermatthewr largeformathistologymayaidinthedetectionofunsuspectedpathologicfindingsofpotentialclinicalsignificanceaprospectivemultiyearsingleinstitutionstudy
AT harrislauren largeformathistologymayaidinthedetectionofunsuspectedpathologicfindingsofpotentialclinicalsignificanceaprospectivemultiyearsingleinstitutionstudy
AT biesemierkarlw largeformathistologymayaidinthedetectionofunsuspectedpathologicfindingsofpotentialclinicalsignificanceaprospectivemultiyearsingleinstitutionstudy