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On Enzyme-Based Anticancer Molecular Dietary Manipulations
Evidence from both epidemiological and experimental observations has fuelled the belief that the high consumption of fruits and vegetables rich in nutrients and phytochemicals may help prevent cancer and heart disease in humans. This concept has been drastically simplified from the dietary approache...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461303/ https://www.ncbi.nlm.nih.gov/pubmed/23049243 http://dx.doi.org/10.1155/2012/790987 |
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author | Sapone, Andrea Canistro, Donatella Melega, Simone Moles, Ramona Vivarelli, Fabio Paolini, Moreno |
author_facet | Sapone, Andrea Canistro, Donatella Melega, Simone Moles, Ramona Vivarelli, Fabio Paolini, Moreno |
author_sort | Sapone, Andrea |
collection | PubMed |
description | Evidence from both epidemiological and experimental observations has fuelled the belief that the high consumption of fruits and vegetables rich in nutrients and phytochemicals may help prevent cancer and heart disease in humans. This concept has been drastically simplified from the dietary approaches to the use of single bioactive components both as a single supplement or in functional foods to manipulate xenobiotic metabolism. These procedures, which aim to induce mutagen/carcinogen detoxification or inhibit their bioactivation, fail to take into account the multiple and paradoxical biological outcomes of enzyme modulators that make their effects unpredictable. Here, we show that the idea that the physiological roles of specific catalysts may be easily manipulated by regular long-term administration of isolated nutrients and other chemicals derived from food plants is not viable. In contrast, we claim that the consumption of healthy diets is most likely to reduce mutagenesis and cancer risk, and that both research endeavours and dietary recommendations should be redirected away from single molecules to dietary patterns as a main strategy for public health policy. |
format | Online Article Text |
id | pubmed-3461303 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34613032012-10-04 On Enzyme-Based Anticancer Molecular Dietary Manipulations Sapone, Andrea Canistro, Donatella Melega, Simone Moles, Ramona Vivarelli, Fabio Paolini, Moreno J Biomed Biotechnol Review Article Evidence from both epidemiological and experimental observations has fuelled the belief that the high consumption of fruits and vegetables rich in nutrients and phytochemicals may help prevent cancer and heart disease in humans. This concept has been drastically simplified from the dietary approaches to the use of single bioactive components both as a single supplement or in functional foods to manipulate xenobiotic metabolism. These procedures, which aim to induce mutagen/carcinogen detoxification or inhibit their bioactivation, fail to take into account the multiple and paradoxical biological outcomes of enzyme modulators that make their effects unpredictable. Here, we show that the idea that the physiological roles of specific catalysts may be easily manipulated by regular long-term administration of isolated nutrients and other chemicals derived from food plants is not viable. In contrast, we claim that the consumption of healthy diets is most likely to reduce mutagenesis and cancer risk, and that both research endeavours and dietary recommendations should be redirected away from single molecules to dietary patterns as a main strategy for public health policy. Hindawi Publishing Corporation 2012 2012-09-20 /pmc/articles/PMC3461303/ /pubmed/23049243 http://dx.doi.org/10.1155/2012/790987 Text en Copyright © 2012 Andrea Sapone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sapone, Andrea Canistro, Donatella Melega, Simone Moles, Ramona Vivarelli, Fabio Paolini, Moreno On Enzyme-Based Anticancer Molecular Dietary Manipulations |
title | On Enzyme-Based Anticancer Molecular Dietary Manipulations |
title_full | On Enzyme-Based Anticancer Molecular Dietary Manipulations |
title_fullStr | On Enzyme-Based Anticancer Molecular Dietary Manipulations |
title_full_unstemmed | On Enzyme-Based Anticancer Molecular Dietary Manipulations |
title_short | On Enzyme-Based Anticancer Molecular Dietary Manipulations |
title_sort | on enzyme-based anticancer molecular dietary manipulations |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461303/ https://www.ncbi.nlm.nih.gov/pubmed/23049243 http://dx.doi.org/10.1155/2012/790987 |
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