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Caloric restriction: is mammalian life extension linked to p53?
Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connec...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461340/ https://www.ncbi.nlm.nih.gov/pubmed/22983298 |
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author | Tucci, Paola |
author_facet | Tucci, Paola |
author_sort | Tucci, Paola |
collection | PubMed |
description | Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarily more ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insights into lifespan modulation. |
format | Online Article Text |
id | pubmed-3461340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-34613402012-10-01 Caloric restriction: is mammalian life extension linked to p53? Tucci, Paola Aging (Albany NY) Review Caloric restriction, that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan, retarding physiological aging and delaying the onset of age-associated diseases. The aim of this mini review is to argue that p53 is the connection in the abilities of both the Sirt-1 pathway and the TOR pathway to impact on longevity of cells and organisms. This novel, lifespan regulating function of p53 may be evolutionarily more ancient than its relatively recent role in apoptosis and tumour suppression, and is likely to provide many new insights into lifespan modulation. Impact Journals LLC 2012-08-22 /pmc/articles/PMC3461340/ /pubmed/22983298 Text en Copyright: © 2012 Tucci http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
spellingShingle | Review Tucci, Paola Caloric restriction: is mammalian life extension linked to p53? |
title | Caloric restriction: is mammalian life extension linked to p53? |
title_full | Caloric restriction: is mammalian life extension linked to p53? |
title_fullStr | Caloric restriction: is mammalian life extension linked to p53? |
title_full_unstemmed | Caloric restriction: is mammalian life extension linked to p53? |
title_short | Caloric restriction: is mammalian life extension linked to p53? |
title_sort | caloric restriction: is mammalian life extension linked to p53? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461340/ https://www.ncbi.nlm.nih.gov/pubmed/22983298 |
work_keys_str_mv | AT tuccipaola caloricrestrictionismammalianlifeextensionlinkedtop53 |