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Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages

The Gram-negative bacterium Shigella flexneri invades the colonic epithelium and causes bacillary dysentery. S. flexneri requires the virulence factor invasion plasmid antigen B (IpaB) to invade host cells, escape from the phagosome and induce macrophage cell death. The mechanism by which IpaB funct...

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Detalles Bibliográficos
Autores principales:	Senerovic, L, Tsunoda, S P, Goosmann, C, Brinkmann, V, Zychlinsky, A, Meissner, F, Kolbe, M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461361/ https://www.ncbi.nlm.nih.gov/pubmed/22951981 http://dx.doi.org/10.1038/cddis.2012.124

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