The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis

This study was aimed to investigate the significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received (18)F-FDG PET/CT scan at initial diagnosis. All patients (18/18) had at least 3 organs involved, with increased FDG metabolism in...

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Detalles Bibliográficos
Autores principales: Zhang, Li-Juan, Xu, Ji, Liu, Peng, Ding, Chong-Yang, Li, Jian-Yong, Qiu, Hong-Xia, Zhang, Su-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461421/
https://www.ncbi.nlm.nih.gov/pubmed/22824539
http://dx.doi.org/10.1186/1756-8722-5-40
Descripción
Sumario:This study was aimed to investigate the significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received (18)F-FDG PET/CT scan at initial diagnosis. All patients (18/18) had at least 3 organs involved, with increased FDG metabolism in different degrees. Fifteen cases (15/18) had definite underlying diseases, including infections (IAHLH), rheumatosis (RAHLH), or malignancy (MAHLH). The SUV(max) of patients in MAHLH group was significantly higher than patients in IAHLH group or RAHLH group (P = 0.015, P = 0.045). Furthermore, the SUV(max) of patients in IAHLH group was significantly higher than patients of RAHLH group (P = 0.043). Therefore, we concluded that (18)F-FDG PET/CT may especially play important role in differential diagnosis of sHLH.

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