The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis

This study was aimed to investigate the significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received (18)F-FDG PET/CT scan at initial diagnosis. All patients (18/18) had at least 3 organs involved, with increased FDG metabolism in...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Li-Juan, Xu, Ji, Liu, Peng, Ding, Chong-Yang, Li, Jian-Yong, Qiu, Hong-Xia, Zhang, Su-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461421/
https://www.ncbi.nlm.nih.gov/pubmed/22824539
http://dx.doi.org/10.1186/1756-8722-5-40
_version_ 1782245072531619840
author Zhang, Li-Juan
Xu, Ji
Liu, Peng
Ding, Chong-Yang
Li, Jian-Yong
Qiu, Hong-Xia
Zhang, Su-Jiang
author_facet Zhang, Li-Juan
Xu, Ji
Liu, Peng
Ding, Chong-Yang
Li, Jian-Yong
Qiu, Hong-Xia
Zhang, Su-Jiang
author_sort Zhang, Li-Juan
collection PubMed
description This study was aimed to investigate the significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received (18)F-FDG PET/CT scan at initial diagnosis. All patients (18/18) had at least 3 organs involved, with increased FDG metabolism in different degrees. Fifteen cases (15/18) had definite underlying diseases, including infections (IAHLH), rheumatosis (RAHLH), or malignancy (MAHLH). The SUV(max) of patients in MAHLH group was significantly higher than patients in IAHLH group or RAHLH group (P = 0.015, P = 0.045). Furthermore, the SUV(max) of patients in IAHLH group was significantly higher than patients of RAHLH group (P = 0.043). Therefore, we concluded that (18)F-FDG PET/CT may especially play important role in differential diagnosis of sHLH.
format Online
Article
Text
id pubmed-3461421
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34614212012-10-02 The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis Zhang, Li-Juan Xu, Ji Liu, Peng Ding, Chong-Yang Li, Jian-Yong Qiu, Hong-Xia Zhang, Su-Jiang J Hematol Oncol Letter to the Editor This study was aimed to investigate the significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received (18)F-FDG PET/CT scan at initial diagnosis. All patients (18/18) had at least 3 organs involved, with increased FDG metabolism in different degrees. Fifteen cases (15/18) had definite underlying diseases, including infections (IAHLH), rheumatosis (RAHLH), or malignancy (MAHLH). The SUV(max) of patients in MAHLH group was significantly higher than patients in IAHLH group or RAHLH group (P = 0.015, P = 0.045). Furthermore, the SUV(max) of patients in IAHLH group was significantly higher than patients of RAHLH group (P = 0.043). Therefore, we concluded that (18)F-FDG PET/CT may especially play important role in differential diagnosis of sHLH. BioMed Central 2012-07-23 /pmc/articles/PMC3461421/ /pubmed/22824539 http://dx.doi.org/10.1186/1756-8722-5-40 Text en Copyright ©2012 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Zhang, Li-Juan
Xu, Ji
Liu, Peng
Ding, Chong-Yang
Li, Jian-Yong
Qiu, Hong-Xia
Zhang, Su-Jiang
The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
title The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
title_full The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
title_fullStr The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
title_full_unstemmed The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
title_short The significance of (18)F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis
title_sort significance of (18)f-fdg pet/ct in secondary hemophagocytic lymphohistiocytosis
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461421/
https://www.ncbi.nlm.nih.gov/pubmed/22824539
http://dx.doi.org/10.1186/1756-8722-5-40
work_keys_str_mv AT zhanglijuan thesignificanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT xuji thesignificanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT liupeng thesignificanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT dingchongyang thesignificanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT lijianyong thesignificanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT qiuhongxia thesignificanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT zhangsujiang thesignificanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT zhanglijuan significanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT xuji significanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT liupeng significanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT dingchongyang significanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT lijianyong significanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT qiuhongxia significanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis
AT zhangsujiang significanceof18ffdgpetctinsecondaryhemophagocyticlymphohistiocytosis

Ejemplares similares