Cargando…

ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion

BACKGROUND: Previous studies suggested that the RhoA/ROCK pathway may contribute to vascular complications in diabetes. The present study was designed to investigate whether ROCK inhibitor fasudil could prevent high glucose-induced monocyte-endothelial cells adhesion, and whether this was related to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hailing, Peng, Wenhui, Jian, Weixia, Li, Yuanmin, Li, Qi, Li, Weiming, Xu, Yawei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461463/ https://www.ncbi.nlm.nih.gov/pubmed/22694757 http://dx.doi.org/10.1186/1475-2840-11-65

Ejemplares similares

The Rho/Rho-associated protein kinase inhibitor fasudil in the protection of endothelial cells against advanced glycation end products through the nuclear factor κB pathway
por: LU, YUYAN, et al.
Publicado: (2013)

Chrysin Attenuates VCAM-1 Expression and Monocyte Adhesion in Lipopolysaccharide-Stimulated Brain Endothelial Cells by Preventing NF-κB Signaling
por: Lee, Bo Kyung, et al.
Publicado: (2017)

Antcin K inhibits VCAM-1-dependent monocyte adhesion in human rheumatoid arthritis synovial fibroblasts
por: Achudhan, David, et al.
Publicado: (2022)

Effect of Flavonoids on MCP-1 Expression in Human Coronary Artery Endothelial Cells and Impact on MCP-1-Dependent Migration of Human Monocytes
por: Brüser, Lea, et al.
Publicado: (2023)

Homocysteinylated Albumin Promotes Increased Monocyte-Endothelial Cell Adhesion and Up-Regulation of MCP1, Hsp60 and ADAM17
por: Capasso, Rosanna, et al.
Publicado: (2012)

Hydrochloride fasudil attenuates brain injury in ICH rats
por: Li, Limin, et al.
Publicado: (2020)

Fasudil improves endothelial dysfunction in rats exposed to chronic intermittent hypoxia through RhoA/ROCK/NFATc3 pathway
por: Li, Jie-Ru, et al.
Publicado: (2018)

Retraction: Homocysteinylated Albumin Promotes Increased Monocyte-Endothelial Cell Adhesion and Up-Regulation of MCP1, Hsp60 and ADAM17
Publicado: (2019)

Proanthocyanidins, from Ribes nigrum leaves, reduce endothelial adhesion molecules ICAM-1 and VCAM-1
por: Garbacki, N, et al.
Publicado: (2005)

Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting
por: Pastorino, Sara, et al.
Publicado: (2021)

NADPH Oxidase/ROS-Dependent VCAM-1 Induction on TNF-α-Challenged Human Cardiac Fibroblasts Enhances Monocyte Adhesion
por: Lin, Chih-Chung, et al.
Publicado: (2016)

IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis
por: Wu, Tsung-Ju, et al.
Publicado: (2022)

Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice
por: Zeng, Peng, et al.
Publicado: (2015)

Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis
por: Koch, Jan C., et al.
Publicado: (2020)

ROCK2 Regulates Monocyte Migration and Cell to Cell Adhesion in Vascular Endothelial Cells
por: Takeda, Yusuke, et al.
Publicado: (2019)

Fasudil attenuates soluble fms-like tyrosine kinase-1 (sFlt-1)-induced hypertension in pregnant mice through RhoA/ROCK pathway
por: Gu, Ying, et al.
Publicado: (2017)

Maprotiline inhibits LPS-induced expression of adhesion molecules (ICAM-1 and VCAM-1) in human endothelial cells
por: Rafiee, Laleh, et al.
Publicado: (2016)

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent
Publicado: (1994)

Attenuation of Diabetic Nephropathy in Diabetic Mice by Fasudil through Regulation of Macrophage Polarization
por: Xie, Fajiang, et al.
Publicado: (2020)

ICAM-1 Clustering on Endothelial Cells Recruits VCAM-1
por: van Buul, Jaap D., et al.
Publicado: (2010)

Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis
por: Yang, Xitong, et al.
Publicado: (2023)

TNF-α-Induced YAP/TAZ Activity Mediates Leukocyte-Endothelial Adhesion by Regulating VCAM1 Expression in Endothelial Cells
por: Choi, Hyun-Jung, et al.
Publicado: (2018)

Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression
por: Li, Xiaosa, et al.
Publicado: (2017)

Elevated VCAM-1, MCP-1 and ADMA serum levels related to pulmonary fibrosis of interstitial lung disease associated with rheumatoid arthritis
por: Pulito-Cueto, Verónica, et al.
Publicado: (2022)

NFAT5 promotes arteriogenesis via MCP‐1‐dependent monocyte recruitment
por: Lin, Xing‐Chi, et al.
Publicado: (2019)

Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1
por: Shi, Liying, et al.
Publicado: (2018)

VLA‐4 Molecules on Tumor Cells Initiate an Adhesive Interaction with VCAM‐1 Molecules on Endothelial Cell Surface
por: Kawaguchi, Satoshi, et al.
Publicado: (1992)

Increased expression of ICAM-1, VCAM-1, MCP-1, and MIP-1α by spinal perivascular macrophages during experimental allergic encephalomyelitis in rats
por: Hofmann, Nils, et al.
Publicado: (2002)

A ROCK1 Inhibitior Fasudil Alleviates Cardiomyocyte Apoptosis in Diabetic Cardiomyopathy by Inhibiting Mitochondrial Fission in a Type 2 Diabetes Mouse Model
por: Fan, Xinhui, et al.
Publicado: (2022)

The role of the chemokines MCP-1, GRO-α, IL-8 and their receptors in the adhesion of monocytic cells to human atherosclerotic plaques
por: Papadopoulou, Charikleia, et al.
Publicado: (2008)

Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE(−/−) mice
por: LIN, YING, et al.
Publicado: (2016)

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
por: Tatenhorst, Lars, et al.
Publicado: (2016)

Flaxseed Prevents Leukocyte and Platelet Adhesion to Endothelial Cells in Experimental Atherosclerosis by Reducing sVCAM-1 and vWF
por: Haliga, Raluca Ecaterina, et al.
Publicado: (2013)

FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity
por: Xin, Yan-Le, et al.
Publicado: (2015)

Decreased Serum Monocyte Chemoattractant Protein-1 (MCP-1) Expression in Patients with Upper Gastrointestinal Bleeding
por: Xing, Guohui, et al.
Publicado: (2019)

Piper sarmentosum attenuates TNF-α-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells
por: Ismail, Siti M., et al.
Publicado: (2018)

Effect of PKC-β Signaling Pathway on Expression of MCP-1 and VCAM-1 in Different Cell Models in Response to Advanced Glycation End Products (AGEs)
por: Rempel, Lisienny C. T., et al.
Publicado: (2015)

Clinical diagnostic value of combined detection of IMA, D-D and MCP-1 in acute myocardial infarction
por: Ding, Mei, et al.
Publicado: (2021)

Vinpocetine Attenuates Neointimal Hyperplasia in Diabetic Rat Carotid Arteries after Balloon Injury
por: Wang, Ke, et al.
Publicado: (2014)

TNF-α Inhibitors in Combination with MTX Reduce Circulating Levels of Heparan Sulfate/Heparin and Endothelial Dysfunction Biomarkers (sVCAM-1, MCP-1, MMP-9 and ADMA) in Women with Rheumatoid Arthritis
por: Szeremeta, Anna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_blcvcluatm2ojdoj7tvuucvaca