Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?

Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling proteins such as ryanodine receptor (RyR), L-type calcium...

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Detalles Bibliográficos
Autores principales: Sankaranarayanan, Rajiv, Venetucci, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461578/
https://www.ncbi.nlm.nih.gov/pubmed/23060805
http://dx.doi.org/10.3389/fphys.2012.00373
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author Sankaranarayanan, Rajiv
Venetucci, Luigi
author_facet Sankaranarayanan, Rajiv
Venetucci, Luigi
author_sort Sankaranarayanan, Rajiv
collection PubMed
description Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling proteins such as ryanodine receptor (RyR), L-type calcium current and sodium/calcium exchanger. In this article, we review all the data available on the effects of omega-3 fatty acids on ventricular myocardial calcium handling. In addition we highlight some unanswered questions and discuss possible therapeutic benefits of omega-3 fatty acids.
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spelling pubmed-34615782012-10-11 Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling? Sankaranarayanan, Rajiv Venetucci, Luigi Front Physiol Physiology Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling proteins such as ryanodine receptor (RyR), L-type calcium current and sodium/calcium exchanger. In this article, we review all the data available on the effects of omega-3 fatty acids on ventricular myocardial calcium handling. In addition we highlight some unanswered questions and discuss possible therapeutic benefits of omega-3 fatty acids. Frontiers Media S.A. 2012-10-01 /pmc/articles/PMC3461578/ /pubmed/23060805 http://dx.doi.org/10.3389/fphys.2012.00373 Text en Copyright © 2012 Sankaranarayanan and Venetucci. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Physiology
Sankaranarayanan, Rajiv
Venetucci, Luigi
Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
title Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
title_full Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
title_fullStr Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
title_full_unstemmed Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
title_short Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
title_sort are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461578/
https://www.ncbi.nlm.nih.gov/pubmed/23060805
http://dx.doi.org/10.3389/fphys.2012.00373
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