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EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration

Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lo...

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Autores principales: Collin de l'Hortet, Alexandra, Gilgenkrantz, Hélène, Guidotti, Jacques-Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461622/
https://www.ncbi.nlm.nih.gov/pubmed/23050157
http://dx.doi.org/10.1155/2012/476910
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author Collin de l'Hortet, Alexandra
Gilgenkrantz, Hélène
Guidotti, Jacques-Emmanuel
author_facet Collin de l'Hortet, Alexandra
Gilgenkrantz, Hélène
Guidotti, Jacques-Emmanuel
author_sort Collin de l'Hortet, Alexandra
collection PubMed
description Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle. The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation. Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies.
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spelling pubmed-34616222012-10-04 EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration Collin de l'Hortet, Alexandra Gilgenkrantz, Hélène Guidotti, Jacques-Emmanuel Int J Hepatol Review Article Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery. During this phenomenon, quiescent hepatocytes of the remnant lobes are able to reenter into the cell cycle initiating the G1-S progression synchronously before completing the cell cycle. The major role played by this step of the cell cycle has been emphasized by loss-of-function studies showing a delay or a lack of coordination in the hepatocytes G1-S progression. Two growth factor receptors, c-Met and EGFR, tightly drive this transition. Due to the level of complexity surrounding EGFR signaling, involving numerous ligands, highly controlled regulations and multiple downstream pathways, we chose to focus on the EGFR pathway for this paper. We will first describe the EGFR pathway in its integrity and then address its essential role in the G1/S phase transition for hepatocyte proliferation. Recently, other levels of control have been discovered to monitor this pathway, which will lead us to discuss regulations of the EGFR pathway and highlight the potential effect of misregulations in pathologies. Hindawi Publishing Corporation 2012 2012-09-23 /pmc/articles/PMC3461622/ /pubmed/23050157 http://dx.doi.org/10.1155/2012/476910 Text en Copyright © 2012 Alexandra Collin de l'Hortet et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Collin de l'Hortet, Alexandra
Gilgenkrantz, Hélène
Guidotti, Jacques-Emmanuel
EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_full EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_fullStr EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_full_unstemmed EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_short EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration
title_sort egfr: a master piece in g1/s phase transition of liver regeneration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461622/
https://www.ncbi.nlm.nih.gov/pubmed/23050157
http://dx.doi.org/10.1155/2012/476910
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