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Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing

How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat....

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Detalles Bibliográficos
Autores principales: Chen, Chen, Rodriguez, Francisco C., Read, Heather L., Escabí, Monty A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461703/
https://www.ncbi.nlm.nih.gov/pubmed/23060750
http://dx.doi.org/10.3389/fncir.2012.00062
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author Chen, Chen
Rodriguez, Francisco C.
Read, Heather L.
Escabí, Monty A.
author_facet Chen, Chen
Rodriguez, Francisco C.
Read, Heather L.
Escabí, Monty A.
author_sort Chen, Chen
collection PubMed
description How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and temporal response preferences were compared for neurons found on the same and adjacent tetrodes (ATs), as well as across distant recording sites. We found that neighboring neurons had similar preferences while neurons recorded across distant sites were less similar. Best frequency (BF) was the most correlated parameter between neighboring neurons and BF differences exhibited unique clustering at ~0.3 octave intervals, indicative of the frequency band lamina. Other spectral and temporal parameters of the receptive fields were more similar for neighboring neurons than for those at distant sites and the receptive field similarity was larger for neurons with small differences in BF. Furthermore, correlated firing was stronger for neighboring neuron pairs and increased with proximity and decreasing BF difference. Thus, although response selectivities are quite diverse in the IC, spectral, and temporal preference within a local microcircuit are functionally quite similar. This suggests a scheme where local circuits are organized into zones that are specialized for processing distinct spectrotemporal cues.
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spelling pubmed-34617032012-10-11 Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing Chen, Chen Rodriguez, Francisco C. Read, Heather L. Escabí, Monty A. Front Neural Circuits Neuroscience How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and temporal response preferences were compared for neurons found on the same and adjacent tetrodes (ATs), as well as across distant recording sites. We found that neighboring neurons had similar preferences while neurons recorded across distant sites were less similar. Best frequency (BF) was the most correlated parameter between neighboring neurons and BF differences exhibited unique clustering at ~0.3 octave intervals, indicative of the frequency band lamina. Other spectral and temporal parameters of the receptive fields were more similar for neighboring neurons than for those at distant sites and the receptive field similarity was larger for neurons with small differences in BF. Furthermore, correlated firing was stronger for neighboring neuron pairs and increased with proximity and decreasing BF difference. Thus, although response selectivities are quite diverse in the IC, spectral, and temporal preference within a local microcircuit are functionally quite similar. This suggests a scheme where local circuits are organized into zones that are specialized for processing distinct spectrotemporal cues. Frontiers Media S.A. 2012-09-27 /pmc/articles/PMC3461703/ /pubmed/23060750 http://dx.doi.org/10.3389/fncir.2012.00062 Text en Copyright © 2012 Chen, Rodriguez, Read and Escabí. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Chen, Chen
Rodriguez, Francisco C.
Read, Heather L.
Escabí, Monty A.
Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing
title Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing
title_full Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing
title_fullStr Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing
title_full_unstemmed Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing
title_short Spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing
title_sort spectrotemporal sound preferences of neighboring inferior colliculus neurons: implications for local circuitry and processing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461703/
https://www.ncbi.nlm.nih.gov/pubmed/23060750
http://dx.doi.org/10.3389/fncir.2012.00062
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