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Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report
INTRODUCTION: Many patients with endometriosis are treated with medication or by surgical approaches. However, a small number of patients do not respond to medication and are inoperable because of comorbidities. This case report shows the effectiveness of radiotherapy for refractory endometriosis an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462141/ https://www.ncbi.nlm.nih.gov/pubmed/22989261 http://dx.doi.org/10.1186/1752-1947-6-308 |
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author | Nomiya, Takuma Harada, Mayumi Sudo, Hiroko Ota, Ibuki Ichikawa, Mayumi Suzuki, Motohisa Murakami, Misako Nemoto, Kenji |
author_facet | Nomiya, Takuma Harada, Mayumi Sudo, Hiroko Ota, Ibuki Ichikawa, Mayumi Suzuki, Motohisa Murakami, Misako Nemoto, Kenji |
author_sort | Nomiya, Takuma |
collection | PubMed |
description | INTRODUCTION: Many patients with endometriosis are treated with medication or by surgical approaches. However, a small number of patients do not respond to medication and are inoperable because of comorbidities. This case report shows the effectiveness of radiotherapy for refractory endometriosis and includes a time series of serum estradiol levels. CASE PRESENTATION: A 47-year-old Asian woman presented to our facility with uncontrolled endometriosis refractory to medication. Our patient was considered inoperable because of severe idiopathic thrombocytopenic purpura, and underwent radiotherapy for massive genital bleeding requiring blood transfusions. A radiation dose of 20Gy in 10 fractions was delivered to the pelvis, including the bilateral ovaries, uterus, and myomas. An additional 10Gy in five fractions was delivered to the endometrium to control residual bleeding. Genital bleeding was completely inhibited on day 46 after radiotherapy. Hormonal analysis revealed that radiotherapy induced post-menopausal status. Two years after radiotherapy, atypical genital bleeding had not recurred and has been well controlled without side effects. CONCLUSIONS: Disrupted ovarian function is an adverse effect of radiotherapy. However, radiotherapy can be useful for inducing menopause. In cases of medication-refractory or inoperable endometriosis, radiotherapy would be an effective treatment option. |
format | Online Article Text |
id | pubmed-3462141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34621412012-10-02 Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report Nomiya, Takuma Harada, Mayumi Sudo, Hiroko Ota, Ibuki Ichikawa, Mayumi Suzuki, Motohisa Murakami, Misako Nemoto, Kenji J Med Case Rep Case Report INTRODUCTION: Many patients with endometriosis are treated with medication or by surgical approaches. However, a small number of patients do not respond to medication and are inoperable because of comorbidities. This case report shows the effectiveness of radiotherapy for refractory endometriosis and includes a time series of serum estradiol levels. CASE PRESENTATION: A 47-year-old Asian woman presented to our facility with uncontrolled endometriosis refractory to medication. Our patient was considered inoperable because of severe idiopathic thrombocytopenic purpura, and underwent radiotherapy for massive genital bleeding requiring blood transfusions. A radiation dose of 20Gy in 10 fractions was delivered to the pelvis, including the bilateral ovaries, uterus, and myomas. An additional 10Gy in five fractions was delivered to the endometrium to control residual bleeding. Genital bleeding was completely inhibited on day 46 after radiotherapy. Hormonal analysis revealed that radiotherapy induced post-menopausal status. Two years after radiotherapy, atypical genital bleeding had not recurred and has been well controlled without side effects. CONCLUSIONS: Disrupted ovarian function is an adverse effect of radiotherapy. However, radiotherapy can be useful for inducing menopause. In cases of medication-refractory or inoperable endometriosis, radiotherapy would be an effective treatment option. BioMed Central 2012-09-18 /pmc/articles/PMC3462141/ /pubmed/22989261 http://dx.doi.org/10.1186/1752-1947-6-308 Text en Copyright ©2012 Nomiya et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Nomiya, Takuma Harada, Mayumi Sudo, Hiroko Ota, Ibuki Ichikawa, Mayumi Suzuki, Motohisa Murakami, Misako Nemoto, Kenji Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report |
title | Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report |
title_full | Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report |
title_fullStr | Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report |
title_full_unstemmed | Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report |
title_short | Radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report |
title_sort | radiotherapy for inoperable and refractory endometriosis presenting with massive hemorrhage: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462141/ https://www.ncbi.nlm.nih.gov/pubmed/22989261 http://dx.doi.org/10.1186/1752-1947-6-308 |
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