Cargando…

Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α

Obesity is associated with tissue hypoxia and the up-regulation of hypoxia inducible factor 1 alpha (HIF-1α). Prior studies in transgenic mice have shown that HIF-1α plays a role in the metabolic dysfunction associated with obesity. Therefore, we hypothesized that, after the development of diet-indu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Mi-Kyung, Drager, Luciano F., Yao, Qiaoling, Bevans-Fonti, Shannon, Yoo, Doo-Young, Jun, Jonathan C., Aja, Susan, Bhanot, Sanjay, Polotsky, Vsevolod Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462192/ https://www.ncbi.nlm.nih.gov/pubmed/23049707 http://dx.doi.org/10.1371/journal.pone.0046562

Ejemplares similares

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease
por: Mesarwi, Omar A., et al.
Publicado: (2016)

High fat diet induces airway hyperresponsiveness in mice
por: Fricke, Kathrin, et al.
Publicado: (2018)

Intermittent Hypoxia Alters Gene Expression in Peripheral Blood Mononuclear Cells of Healthy Volunteers
por: Polotsky, Vsevolod Y., et al.
Publicado: (2015)

Intranasal leptin improves survival after opioid overdose in a mouse model
por: Freire, Carla, et al.
Publicado: (2021)

Caloric restriction prevents the development of airway hyperresponsiveness in mice on a high fat diet
por: Younas, Haris, et al.
Publicado: (2019)

Metformin Alleviates Airway Hyperresponsiveness in a Mouse Model of Diet-Induced Obesity
por: Gu, Chenjuan, et al.
Publicado: (2022)

Metabolic Consequences of Neuronal HIF1α-Deficiency in Mediobasal Hypothalamus in Mice
por: Rozjan, Azmat, et al.
Publicado: (2021)

Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity
por: Kim, Lenise J., et al.
Publicado: (2021)

Metformin Attenuates Cardiac Hypertrophy Via the HIF-1α/PPAR-γ Signaling Pathway in High-Fat Diet Rats
por: Liu, Yuansheng, et al.
Publicado: (2022)

Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep Apnea: A Possible Link to Oxidative Stress and Cardiovascular Complications
por: Berger, Slava, et al.
Publicado: (2018)

High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice
por: Skaznik-Wikiel, Malgorzata E., et al.
Publicado: (2016)

Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease: Is the Liver Another Target?
por: Mirrakhimov, Aibek E., et al.
Publicado: (2012)

Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets
por: Kim, Lenise J., et al.
Publicado: (2020)

Sleep apnea predicts distinct alterations in glucose homeostasis and biomarkers in obese adults with normal and impaired glucose metabolism
por: Pallayova, Maria, et al.
Publicado: (2010)

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice
por: Sussan, Thomas E., et al.
Publicado: (2008)

Bortezomib attenuates HIF-1- but not HIF-2-mediated transcriptional activation
por: ABD-AZIZ, NORAINI, et al.
Publicado: (2015)

Pharmacotherapy of Obstructive Sleep Apnea: Is Salvation Just Around a Corner?
por: Fleury Curado, Thomaz, et al.
Publicado: (2019)

Of Mice and Babies: PHOX2B and Obstructive Apneas in Congenital Central Hypoventilation Syndrome
por: Amorim, Mateus Ramos, et al.
Publicado: (2021)

Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction
por: Kim, Yo Na, et al.
Publicado: (2021)

The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet
por: Glastras, Sarah J., et al.
Publicado: (2017)

Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice
por: Shin, Mi Kyung, et al.
Publicado: (2020)

Phlorizin Supplementation Attenuates Obesity, Inflammation, and Hyperglycemia in Diet-Induced Obese Mice Fed a High-Fat Diet
por: Shin, Su-Kyung, et al.
Publicado: (2016)

Sleep Apnea, Hypoxia Inducible Factor, and Fatty Liver: More Questions Than Answers?
por: Kim, Lenise J., et al.
Publicado: (2021)

Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
por: Krüger, Janine, et al.
Publicado: (2013)

Asiatic acid attenuates high-fat diet-induced impaired spermatogenesis
por: Miao, Xi-Li, et al.
Publicado: (2018)

Dieckol-Attenuated High-Fat Diet Induced Muscle Atrophy by Modulating Muscular Deposition of Lipid Droplets
por: Byun, Kyung-A, et al.
Publicado: (2021)

Consequences of Exchanging Carbohydrates for Proteins in the Cholesterol Metabolism of Mice Fed a High-fat Diet
por: Raymond, Frédéric, et al.
Publicado: (2012)

Consequences of a Maternal High-Fat Diet and Late Gestation Diabetes on the Developing Rat Lung
por: Baack, Michelle L., et al.
Publicado: (2016)

Myeloid-specific deletion of NOX2 prevents the metabolic and neurologic consequences of high fat diet
por: Pepping, Jennifer K., et al.
Publicado: (2017)

Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice
por: Lee, Seung-Wook, et al.
Publicado: (2017)

Fructus Xanthii Attenuates Hepatic Steatosis in Rats Fed on High-Fat Diet
por: Li, Xiumin, et al.
Publicado: (2013)

Edible bird’s nest attenuates procoagulation effects of high-fat diet in rats
por: Yida, Zhang, et al.
Publicado: (2015)

Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy
por: Liu, Kun, et al.
Publicado: (2019)

Pharmacological HIF-inhibition attenuates postoperative adhesion formation
por: Strowitzki, Moritz J., et al.
Publicado: (2017)

Korean Pine Nut Oil Attenuated Hepatic Triacylglycerol Accumulation in High-Fat Diet-Induced Obese Mice
por: Park, Soyoung, et al.
Publicado: (2016)

Leuconostoc mesenteroides mediates an electrogenic pathway to attenuate the accumulation of abdominal fat mass induced by high fat diet
por: Pham, Minh Tan, et al.
Publicado: (2020)

ACOT1 deficiency attenuates high-fat diet–induced fat mass gain by increasing energy expenditure
por: Heden, Timothy D., et al.
Publicado: (2023)

Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice
por: Kim, Kyung Eun, et al.
Publicado: (2016)

EGCG Attenuates Autoimmune Arthritis by Inhibition of STAT3 and HIF-1α with Th17/Treg Control
por: Yang, Eun-Ji, et al.
Publicado: (2014)

PSUN111 Rationale and Design of the Dinner Time 2 Trial: A Randomized, Crossover Trial to Compare the Effects of Delayed Eating vs Delayed Sleeping on Overnight Metabolism in Healthy Volunteers
por: Duan, Daisy, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8ut8tqtp626qmc8fqte4q3jhcm