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Assaying the Kinase Activity of LRRK2 in vitro

Leucine Rich Repeat Kinase 2 (LRRK2) is a 2527 amino acid member of the ROCO family of proteins, possessing a complex, multidomain structure including a GTPase domain (termed ROC, for Ras of Complex proteins) and a kinase domain(1). The discovery in 2004 of mutations in LRRK2 that cause Parkinson�...

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Detalles Bibliográficos
Autor principal:	Lewis, Patrick A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MyJove Corporation 2012
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462557/ https://www.ncbi.nlm.nih.gov/pubmed/22301813 http://dx.doi.org/10.3791/3495

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