Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)/calmodulin-dependent kinase ll in retinal capillary endothelial cells

PURPOSE: Hyperglycemia-induced vascular cell apoptosis is a seminal early event in diabetic retinopathy. Prolonged hyperglycemia is known to increase intracellular cytosolic free calcium ([Ca(2+)]i) in retinal vascular endothelial cells (RECs), suggesting that [Ca(2+)]i is a critical trigger for mic...

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Detalles Bibliográficos
Autores principales: Li, Jun, Wang, Peipei, Yu, Songping, Zheng, Zhi, Xu, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462598/
https://www.ncbi.nlm.nih.gov/pubmed/23049237

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