Erioflorin Stabilizes the Tumor Suppressor Pdcd4 by Inhibiting Its Interaction with the E3-ligase β-TrCP1

Loss of the tumor suppressor Pdcd4 was reported for various tumor entities and proposed as a prognostic marker in tumorigenesis. We previously characterized decreased Pdcd4 protein stability in response to mitogenic stimuli, which resulted from p70(S6K1)-dependent protein phosphorylation, β-TrCP1-me...

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Detalles Bibliográficos
Autores principales: Blees, Johanna S., Bokesch, Heidi R., Rübsamen, Daniela, Schulz, Kathrin, Milke, Larissa, Bajer, Magdalena M., Gustafson, Kirk R., Henrich, Curtis J., McMahon, James B., Colburn, Nancy H., Schmid, Tobias, Brüne, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462793/
https://www.ncbi.nlm.nih.gov/pubmed/23056346
http://dx.doi.org/10.1371/journal.pone.0046567

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