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Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan

BACKGROUND: Pilocytic Astrocytoma (PA) is a common type of brain tumor in the pediatric population. They have a fairly good prognosis. This study describes PAs in detail, with a focus on the demographic factors, presenting features, management and prognosis, and aims, to identify the negative outcom...

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Autores principales: Khan, Muhib A., Godil, Saniya S., Tabani, Halima, Panju, Sukaina A., Enam, Syed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463151/
https://www.ncbi.nlm.nih.gov/pubmed/23050204
http://dx.doi.org/10.4103/2152-7806.99936
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author Khan, Muhib A.
Godil, Saniya S.
Tabani, Halima
Panju, Sukaina A.
Enam, Syed A.
author_facet Khan, Muhib A.
Godil, Saniya S.
Tabani, Halima
Panju, Sukaina A.
Enam, Syed A.
author_sort Khan, Muhib A.
collection PubMed
description BACKGROUND: Pilocytic Astrocytoma (PA) is a common type of brain tumor in the pediatric population. They have a fairly good prognosis. This study describes PAs in detail, with a focus on the demographic factors, presenting features, management and prognosis, and aims, to identify the negative outcome predictors in our population, which can affect the course of the disease. This article will add to the understanding of PAs from a third world perspective. METHODS: The Aga Khan University medical records (1995 – 2007) were reviewed, to study the clinical features, management, and outcome of patients (0 – 15 years) with Pilocytic Astrocytomas (PAs) in our population. After a thorough review of the medical records, all the PAs diagnosed on the basis of histopathology at our Pathology Laboratory, during this period, were included in the study. RESULTS: Twenty-two patients were included with a mean age of 9.25 years. Male-to-female ratio was 1 : 1. The most common presenting feature was a sign of increased intracranial pressure. The most common location was the cerebellum followed by the cerebrum. Fifteen patients underwent maximum surgical resection. Three had recurrence, despite no residual tumor. There were 10 Intensive Care Unit (ICU) admissions and one inpatient mortality. Fifteen patients followed up in the clinic: Eight had recurrence and four underwent repeat surgery (three showed clinical improvement). Hydrocephalus was a predictor of ICU admission. Solid consistency was found to be a marker of recurrence. CONCLUSION: Pilocytic Astrocytomas are the most common pediatric brain tumors in our population, commonly located in the cerebellum. Complete resection is the best treatment option, but some tumors are aggressive and recurrence is not uncommon. The possible negative outcome predictors are age, source of admission, extent of resection, hydrocephalus, and solid consistency.
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spelling pubmed-34631512012-10-04 Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan Khan, Muhib A. Godil, Saniya S. Tabani, Halima Panju, Sukaina A. Enam, Syed A. Surg Neurol Int Original Article BACKGROUND: Pilocytic Astrocytoma (PA) is a common type of brain tumor in the pediatric population. They have a fairly good prognosis. This study describes PAs in detail, with a focus on the demographic factors, presenting features, management and prognosis, and aims, to identify the negative outcome predictors in our population, which can affect the course of the disease. This article will add to the understanding of PAs from a third world perspective. METHODS: The Aga Khan University medical records (1995 – 2007) were reviewed, to study the clinical features, management, and outcome of patients (0 – 15 years) with Pilocytic Astrocytomas (PAs) in our population. After a thorough review of the medical records, all the PAs diagnosed on the basis of histopathology at our Pathology Laboratory, during this period, were included in the study. RESULTS: Twenty-two patients were included with a mean age of 9.25 years. Male-to-female ratio was 1 : 1. The most common presenting feature was a sign of increased intracranial pressure. The most common location was the cerebellum followed by the cerebrum. Fifteen patients underwent maximum surgical resection. Three had recurrence, despite no residual tumor. There were 10 Intensive Care Unit (ICU) admissions and one inpatient mortality. Fifteen patients followed up in the clinic: Eight had recurrence and four underwent repeat surgery (three showed clinical improvement). Hydrocephalus was a predictor of ICU admission. Solid consistency was found to be a marker of recurrence. CONCLUSION: Pilocytic Astrocytomas are the most common pediatric brain tumors in our population, commonly located in the cerebellum. Complete resection is the best treatment option, but some tumors are aggressive and recurrence is not uncommon. The possible negative outcome predictors are age, source of admission, extent of resection, hydrocephalus, and solid consistency. Medknow Publications & Media Pvt Ltd 2012-08-21 /pmc/articles/PMC3463151/ /pubmed/23050204 http://dx.doi.org/10.4103/2152-7806.99936 Text en Copyright: © 2012 Khan MA. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Khan, Muhib A.
Godil, Saniya S.
Tabani, Halima
Panju, Sukaina A.
Enam, Syed A.
Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan
title Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan
title_full Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan
title_fullStr Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan
title_full_unstemmed Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan
title_short Clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in Pakistan
title_sort clinical review of pediatric pilocytic astrocytomas treated at a tertiary care hospital in pakistan
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463151/
https://www.ncbi.nlm.nih.gov/pubmed/23050204
http://dx.doi.org/10.4103/2152-7806.99936
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