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Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus

Studies of the response of the immune system to feline immunodeficiency virus (FIV) during primary infection have shown that a subpopulation of CD8(+) T-cells with an activated phenotype and reduced expression of the CD8β chain (denoted CD8β (low) T cells) expands to reach up to 80% of the total CD8...

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Autores principales: Ribba, B., El Garch, H., Brunet, S., Grenier, E., Castiglione, F., Poulet, H., Vanhems, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463190/
https://www.ncbi.nlm.nih.gov/pubmed/23049618
http://dx.doi.org/10.1155/2012/342602
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author Ribba, B.
El Garch, H.
Brunet, S.
Grenier, E.
Castiglione, F.
Poulet, H.
Vanhems, P.
author_facet Ribba, B.
El Garch, H.
Brunet, S.
Grenier, E.
Castiglione, F.
Poulet, H.
Vanhems, P.
author_sort Ribba, B.
collection PubMed
description Studies of the response of the immune system to feline immunodeficiency virus (FIV) during primary infection have shown that a subpopulation of CD8(+) T-cells with an activated phenotype and reduced expression of the CD8β chain (denoted CD8β (low) T cells) expands to reach up to 80% of the total CD8(+) T cell count. The expansion of this subpopulation is considered to be a signature of FIV and an indicator of immune system alteration. We use a simple mathematical formalism to study the relationships over time between the dose of infection, the size of the CD8β (low) population, and the circulating viral load in cats infected with FIV. Viremia profiles are described using a combination of two exponential laws, whereas the CD8β (low) percentage (out of the total CD8(+) population) is represented by a Gompertz law including an expansion phase and a saturation phase. Model parameters are estimated with a population approach using data from 102 experimentally infected cats. We examine the dose of infection as a potential covariate of parameters. We find that the rates of increase of viral load and of CD8β (low) percentage are both correlated with the dose of infection. Cats that develop strong acute viremia also show the largest degree of CD8β (low) expansion. The two simple models are robust tools for analysing the time course of CD8β (low) percentage and circulating viral load in FIV-infected cats and may be useful for generating new insights on the disease and on the design of therapeutic strategies, potentially applicable to HIV infection.
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spelling pubmed-34631902012-10-04 Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus Ribba, B. El Garch, H. Brunet, S. Grenier, E. Castiglione, F. Poulet, H. Vanhems, P. Comput Math Methods Med Research Article Studies of the response of the immune system to feline immunodeficiency virus (FIV) during primary infection have shown that a subpopulation of CD8(+) T-cells with an activated phenotype and reduced expression of the CD8β chain (denoted CD8β (low) T cells) expands to reach up to 80% of the total CD8(+) T cell count. The expansion of this subpopulation is considered to be a signature of FIV and an indicator of immune system alteration. We use a simple mathematical formalism to study the relationships over time between the dose of infection, the size of the CD8β (low) population, and the circulating viral load in cats infected with FIV. Viremia profiles are described using a combination of two exponential laws, whereas the CD8β (low) percentage (out of the total CD8(+) population) is represented by a Gompertz law including an expansion phase and a saturation phase. Model parameters are estimated with a population approach using data from 102 experimentally infected cats. We examine the dose of infection as a potential covariate of parameters. We find that the rates of increase of viral load and of CD8β (low) percentage are both correlated with the dose of infection. Cats that develop strong acute viremia also show the largest degree of CD8β (low) expansion. The two simple models are robust tools for analysing the time course of CD8β (low) percentage and circulating viral load in FIV-infected cats and may be useful for generating new insights on the disease and on the design of therapeutic strategies, potentially applicable to HIV infection. Hindawi Publishing Corporation 2012 2012-09-25 /pmc/articles/PMC3463190/ /pubmed/23049618 http://dx.doi.org/10.1155/2012/342602 Text en Copyright © 2012 B. Ribba et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ribba, B.
El Garch, H.
Brunet, S.
Grenier, E.
Castiglione, F.
Poulet, H.
Vanhems, P.
Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus
title Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus
title_full Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus
title_fullStr Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus
title_full_unstemmed Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus
title_short Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus
title_sort time-course analysis of main markers of primary infection in cats with the feline immunodeficiency virus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463190/
https://www.ncbi.nlm.nih.gov/pubmed/23049618
http://dx.doi.org/10.1155/2012/342602
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