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Alternative Modes of Binding of Poly(ADP-ribose) Polymerase 1 to Free DNA and Nucleosomes

Poly(ADP-ribose) polymerase 1 (PARP-1) is an abundant nuclear protein that binds chromatin and catalyzes the transfer of ADP-ribose groups to itself and to numerous target proteins upon interacting with damaged DNA. The molecular basis for the dual role of PARP-1 as a chromatin architectural protein...

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Detalles Bibliográficos
Autores principales:	Clark, Nicholas J., Kramer, Michael, Muthurajan, Uma M., Luger, Karolin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463355/ https://www.ncbi.nlm.nih.gov/pubmed/22854955 http://dx.doi.org/10.1074/jbc.M112.397067

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