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Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life
Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism. In contrast to protein restriction during fetal life, protein restriction during lactation did not appear to cause either obesity or the hallm...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463445/ https://www.ncbi.nlm.nih.gov/pubmed/22967456 http://dx.doi.org/10.1186/1743-7075-9-80 |
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author | de Oliveira, Júlio Cezar Grassiolli, Sabrina Gravena, Clarice de Mathias, Paulo Cezar Freitas |
author_facet | de Oliveira, Júlio Cezar Grassiolli, Sabrina Gravena, Clarice de Mathias, Paulo Cezar Freitas |
author_sort | de Oliveira, Júlio Cezar |
collection | PubMed |
description | Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism. In contrast to protein restriction during fetal life, protein restriction during lactation did not appear to cause either obesity or the hallmarks of metabolic syndrome, such as hyperinsulinemia, when individuals reached adulthood. However, protein restriction provokes body underweight and hypoinsulinemia. This review is focused on the regulation of insulin secretion and the influence of the autonomic nervous system (ANS) in adult rats that were protein-malnourished during lactation. The data available on the topic suggest that the perinatal phase of lactation, when insulted by protein deficit, imprints the adult metabolism and thereby alters the glycemic control. Although hypoinsulinemia programs adult rats to maintain normoglycemia, pancreatic β-cells are less sensitive to secretion stimuli, such as glucose and cholinergic agents. These pancreatic dysfunctions may be attributed to an imbalance of ANS activity recorded in adult rats that experienced maternal protein restriction. |
format | Online Article Text |
id | pubmed-3463445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34634452012-10-04 Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life de Oliveira, Júlio Cezar Grassiolli, Sabrina Gravena, Clarice de Mathias, Paulo Cezar Freitas Nutr Metab (Lond) Review Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism. In contrast to protein restriction during fetal life, protein restriction during lactation did not appear to cause either obesity or the hallmarks of metabolic syndrome, such as hyperinsulinemia, when individuals reached adulthood. However, protein restriction provokes body underweight and hypoinsulinemia. This review is focused on the regulation of insulin secretion and the influence of the autonomic nervous system (ANS) in adult rats that were protein-malnourished during lactation. The data available on the topic suggest that the perinatal phase of lactation, when insulted by protein deficit, imprints the adult metabolism and thereby alters the glycemic control. Although hypoinsulinemia programs adult rats to maintain normoglycemia, pancreatic β-cells are less sensitive to secretion stimuli, such as glucose and cholinergic agents. These pancreatic dysfunctions may be attributed to an imbalance of ANS activity recorded in adult rats that experienced maternal protein restriction. BioMed Central 2012-09-11 /pmc/articles/PMC3463445/ /pubmed/22967456 http://dx.doi.org/10.1186/1743-7075-9-80 Text en Copyright ©2012 de Oliveira et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review de Oliveira, Júlio Cezar Grassiolli, Sabrina Gravena, Clarice de Mathias, Paulo Cezar Freitas Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life |
title | Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life |
title_full | Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life |
title_fullStr | Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life |
title_full_unstemmed | Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life |
title_short | Early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life |
title_sort | early postnatal low-protein nutrition, metabolic programming and the autonomic nervous system in adult life |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463445/ https://www.ncbi.nlm.nih.gov/pubmed/22967456 http://dx.doi.org/10.1186/1743-7075-9-80 |
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