A Cardiac-Specific Robotized Cellular Assay Identified Families of Human Ligands as Inducers of PGC-1α Expression and Mitochondrial Biogenesis

BACKGROUND: Mitochondrial function is dramatically altered in heart failure (HF). This is associated with a decrease in the expression of the transcriptional coactivator PGC-1α, which plays a key role in the coordination of energy metabolism. Identification of compounds able to activate PGC-1α trans...

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Detalles Bibliográficos
Autores principales: Ruiz, Matthieu, Courilleau, Delphine, Jullian, Jean-Christophe, Fortin, Dominique, Ventura-Clapier, Renée, Blondeau, Jean-Paul, Garnier, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463514/
https://www.ncbi.nlm.nih.gov/pubmed/23056435
http://dx.doi.org/10.1371/journal.pone.0046753

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