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Evolutionary Analysis of Classical HLA Class I and II Genes Suggests That Recent Positive Selection Acted on DPB1*04∶01 in Japanese Population

The human leukocyte antigen (HLA) genes exhibit the highest degree of polymorphism in the human genome. This high degree of variation at classical HLA class I and class II loci has been maintained by balancing selection for a long evolutionary time. However, little is known about recent positive sel...

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Detalles Bibliográficos
Autores principales:	Kawashima, Minae, Ohashi, Jun, Nishida, Nao, Tokunaga, Katsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463557/ https://www.ncbi.nlm.nih.gov/pubmed/23056460 http://dx.doi.org/10.1371/journal.pone.0046806

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