Designing and Testing Broadly-Protective Filoviral Vaccines Optimized for Cytotoxic T-Lymphocyte Epitope Coverage

We report the rational design and in vivo testing of mosaic proteins for a polyvalent pan-filoviral vaccine using a computational strategy designed for the Human Immunodeficiency Virus type 1 (HIV-1) but also appropriate for Hepatitis C virus (HCV) and potentially other diverse viruses. Mosaics are...

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Detalles Bibliográficos
Autores principales: Fenimore, Paul W., Muhammad, Majidat A., Fischer, William M., Foley, Brian T., Bakken, Russell R., Thurmond, James R., Yusim, Karina, Yoon, Hyejin, Parker, Michael, Hart, Mary Kate, Dye, John M., Korber, Bette, Kuiken, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463593/
https://www.ncbi.nlm.nih.gov/pubmed/23056184
http://dx.doi.org/10.1371/journal.pone.0044769

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