Association Study of Gene LPP in Women with Polycystic Ovary Syndrome

BACKGROUND: Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP g...

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Detalles Bibliográficos
Autores principales: Zhang, Bo, Zhao, Han, Li, Tao, Gao, Xuan, Gao, Qin, Tang, Rong, Zhang, Jiangtao, Chen, Zi-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463595/
https://www.ncbi.nlm.nih.gov/pubmed/23056290
http://dx.doi.org/10.1371/journal.pone.0046370
Descripción
Sumario:BACKGROUND: Previous genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS. METHODS: Three polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method. RESULTS: In rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (P(meta) = 1.89E-05, OR = 1.23), rs4449306 (P(meta) = 3.0E-04, OR = 1.10), rs6782041 (P(meta) = 2.0E-04, OR = 1.09), were significantly different between PCOS cases and controls. CONCLUSIONS: Our results suggest that LPP gene might be a novel candidate for PCOS.

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