Activity of the Upstream Component of Tandem TERT/Survivin Promoters Depends on Features of the Downstream Component

We spliced the promoters of the human telomerase and human survivin genes (PhTERT and PhSurv, respectively) widely used for gene therapy and known to have the broadest cancer type spectrum of activity. Two head-to-tail constructs were obtained: the PhTERT-PhSurv and PhSurv-PhTERT tandems. The splici...

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Detalles Bibliográficos
Autores principales: Alekseenko, Irina V., Pleshkan, Victor V., Kopantzev, Eugene P., Stukacheva, Elena A., Chernov, Igor P., Vinogradova, Tatyana V., Sverdlov, Eugene D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463601/
https://www.ncbi.nlm.nih.gov/pubmed/23056318
http://dx.doi.org/10.1371/journal.pone.0046474

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