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Chemical Analysis and Transplacental Transfer of Oseltamivir and Oseltamivir Carboxylic Acid in Pregnant Rats

In view of the limited information on the pharmacokinetics of oseltamivir (OSE) during pregnancy, this study aims to evaluate the placental transportation of OSE and its active metabolite oseltamivir carboxylic acid (OCA) in rats. A validated liquid chromatography-tandem mass spectrometry (LC-MS/MS)...

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Detalles Bibliográficos
Autores principales: Lin, Chia-Chun, Yen, Jiin-Cherng, Wu, Yu-Tse, Lin, Lie-Chwen, Tsai, Tung-Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463610/
https://www.ncbi.nlm.nih.gov/pubmed/23056234
http://dx.doi.org/10.1371/journal.pone.0046062

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