The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

Activation of the NF-κB pathway requires the formation of Met1-linked ‘linear’ ubiquitin chains on NEMO, which is catalysed by the Linear Ubiquitin Chain Assembly Complex (LUBAC) E3 consisting of HOIP, HOIL-1L and Sharpin. Here, we show that both LUBAC catalytic activity and LUBAC specificity for li...

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Detalles Bibliográficos
Autores principales: Smit, Judith J, Monteferrario, Davide, Noordermeer, Sylvie M, van Dijk, Willem J, van der Reijden, Bert A, Sixma, Titia K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463842/
https://www.ncbi.nlm.nih.gov/pubmed/22863777
http://dx.doi.org/10.1038/emboj.2012.217

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