Review: apoptotic mechanisms in bacterial infections of the central nervous system

In this article we review the apoptotic mechanisms most frequently encountered in bacterial infections of the central nervous system (CNS). We focus specifically on apoptosis of neural cells (neurons and glia), and provide first an overview of the phenomenon of apoptosis itself and its extrinsic and...

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Detalles Bibliográficos
Autores principales: Parthasarathy, Geetha, Philipp, Mario T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463897/
https://www.ncbi.nlm.nih.gov/pubmed/23060884
http://dx.doi.org/10.3389/fimmu.2012.00306
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author Parthasarathy, Geetha
Philipp, Mario T.
author_facet Parthasarathy, Geetha
Philipp, Mario T.
author_sort Parthasarathy, Geetha
collection PubMed
description In this article we review the apoptotic mechanisms most frequently encountered in bacterial infections of the central nervous system (CNS). We focus specifically on apoptosis of neural cells (neurons and glia), and provide first an overview of the phenomenon of apoptosis itself and its extrinsic and intrinsic pathways. We then describe apoptosis in the context of infectious diseases and inflammation caused by bacteria, and review its role in the pathogenesis of the most relevant bacterial infections of the CNS.
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spelling pubmed-34638972012-10-11 Review: apoptotic mechanisms in bacterial infections of the central nervous system Parthasarathy, Geetha Philipp, Mario T. Front Immunol Immunology In this article we review the apoptotic mechanisms most frequently encountered in bacterial infections of the central nervous system (CNS). We focus specifically on apoptosis of neural cells (neurons and glia), and provide first an overview of the phenomenon of apoptosis itself and its extrinsic and intrinsic pathways. We then describe apoptosis in the context of infectious diseases and inflammation caused by bacteria, and review its role in the pathogenesis of the most relevant bacterial infections of the CNS. Frontiers Media S.A. 2012-10-04 /pmc/articles/PMC3463897/ /pubmed/23060884 http://dx.doi.org/10.3389/fimmu.2012.00306 Text en Copyright © 2012 Parthasarathy and Philipp. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Immunology
Parthasarathy, Geetha
Philipp, Mario T.
Review: apoptotic mechanisms in bacterial infections of the central nervous system
title Review: apoptotic mechanisms in bacterial infections of the central nervous system
title_full Review: apoptotic mechanisms in bacterial infections of the central nervous system
title_fullStr Review: apoptotic mechanisms in bacterial infections of the central nervous system
title_full_unstemmed Review: apoptotic mechanisms in bacterial infections of the central nervous system
title_short Review: apoptotic mechanisms in bacterial infections of the central nervous system
title_sort review: apoptotic mechanisms in bacterial infections of the central nervous system
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463897/
https://www.ncbi.nlm.nih.gov/pubmed/23060884
http://dx.doi.org/10.3389/fimmu.2012.00306
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