Superior Silencing by 2′,4′-BNA(NC)-Based Short Antisense Oligonucleotides Compared to 2′,4′-BNA/LNA-Based Apolipoprotein B Antisense Inhibitors

The duplex stability with target mRNA and the gene silencing potential of a novel bridged nucleic acid analogue are described. The analogue, 2′,4′-BNA(NC) antisense oligonucleotides (AONs) ranging from 10- to 20-nt-long, targeted apolipoprotein B. 2′,4′-BNA(NC) was directly compared to its conventio...

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Detalles Bibliográficos
Autores principales: Yamamoto, Tsuyoshi, Yasuhara, Hidenori, Wada, Fumito, Harada-Shiba, Mariko, Imanishi, Takeshi, Obika, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463943/
https://www.ncbi.nlm.nih.gov/pubmed/23056920
http://dx.doi.org/10.1155/2012/707323

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