Cargando…

Functional Analysis With a Barcoder Yeast Gene Overexpression System

Systematic analysis of gene overexpression phenotypes provides an insight into gene function, enzyme targets, and biological pathways. Here, we describe a novel functional genomics platform that enables a highly parallel and systematic assessment of overexpression phenotypes in pooled cultures. Firs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Douglas, Alison C., Smith, Andrew M., Sharifpoor, Sara, Yan, Zhun, Durbic, Tanja, Heisler, Lawrence E., Lee, Anna Y., Ryan, Owen, Göttert, Hendrikje, Surendra, Anu, van Dyk, Dewald, Giaever, Guri, Boone, Charles, Nislow, Corey, Andrews, Brenda J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2012
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464120/ https://www.ncbi.nlm.nih.gov/pubmed/23050238 http://dx.doi.org/10.1534/g3.112.003400

Ejemplares similares

Competitive Genomic Screens of Barcoded Yeast Libraries
por: Smith, Andrew M., et al.
Publicado: (2011)

A comparative analysis of DNA barcode microarray feature size
por: Ammar, Ron, et al.
Publicado: (2009)

The Yeast Deletion Collection: A Decade of Functional Genomics
por: Giaever, Guri, et al.
Publicado: (2014)

Network dynamics of the yeast methyltransferome
por: Giaever, Guri, et al.
Publicado: (2019)

Chromatin is an ancient innovation conserved between Archaea and Eukarya
por: Ammar, Ron, et al.
Publicado: (2012)

Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast
por: Ericson, Elke, et al.
Publicado: (2008)

An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes
por: Kofoed, Megan, et al.
Publicado: (2015)

A genome scale overexpression screen to reveal drug activity in human cells
por: Arnoldo, Anthony, et al.
Publicado: (2014)

Multiple Means to the Same End: The Genetic Basis of Acquired Stress Resistance in Yeast
por: Berry, David B., et al.
Publicado: (2011)

Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples
por: Smith, Andrew M., et al.
Publicado: (2010)

An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations
por: Shabtai, Daniel, et al.
Publicado: (2012)

Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells
por: Yu, Lisa, et al.
Publicado: (2008)

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action
por: Hillenmeyer, Maureen E, et al.
Publicado: (2010)

A genome-wide portrait of pervasive drug contaminants
por: Ogbede, Joseph Uche, et al.
Publicado: (2021)

Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics
por: Jaime, Maria DLA, et al.
Publicado: (2012)

Interactively AUDIT Your Growth Curves with a Suite of R Packages
por: Coutin, Nicolas P. J., et al.
Publicado: (2020)

The cellular response to drug perturbation is limited: comparison of large-scale chemogenomic fitness signatures
por: Barazandeh, Marjan, et al.
Publicado: (2022)

Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants
por: Hamza, Akil, et al.
Publicado: (2015)

Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs
por: Kittanakom, Saranya, et al.
Publicado: (2013)

Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis
por: Kemmer, Danielle, et al.
Publicado: (2009)

Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations
por: Hammond, Timothy G., et al.
Publicado: (2017)

A comprehensive platform for highly multiplexed mammalian functional genetic screens
por: Ketela, Troy, et al.
Publicado: (2011)

Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c )in Saccharomyces cerevisiae
por: Orij, Rick, et al.
Publicado: (2012)

Systematic Prediction of Antifungal Drug Synergy by Chemogenomic Screening in Saccharomyces cerevisiae
por: Gaikani, Hamid, et al.
Publicado: (2021)

A Global Perspective of the Genetic Basis for Carbonyl Stress Resistance
por: Hoon, Shawn, et al.
Publicado: (2011)

Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant
por: Wong, Lai H., et al.
Publicado: (2017)

Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress
por: Acton, Erica, et al.
Publicado: (2017)

Genes Required for Survival in Microgravity Revealed by Genome-Wide Yeast Deletion Collections Cultured during Spaceflight
por: Nislow, Corey, et al.
Publicado: (2015)

Global analysis of SUMO chain function reveals multiple roles in chromatin regulation
por: Srikumar, Tharan, et al.
Publicado: (2013)

Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae
por: Jo, William J, et al.
Publicado: (2009)

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis
por: Vizeacoumar, Franco J., et al.
Publicado: (2010)

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis
por: Alfred, Simon E, et al.
Publicado: (2012)

Design, Synthesis, and Characterization of a Highly Effective Hog1 Inhibitor: A Powerful Tool for Analyzing MAP Kinase Signaling in Yeast
por: Dinér, Peter, et al.
Publicado: (2011)

Systematic exploration of synergistic drug pairs
por: Cokol, Murat, et al.
Publicado: (2011)

Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation
por: Fabrizio, Paola, et al.
Publicado: (2010)

Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions
por: Wong, Lai H., et al.
Publicado: (2016)

A quantitative literature-curated gold standard for kinase-substrate pairs
por: Sharifpoor, Sara, et al.
Publicado: (2011)

A quantitative literature-curated gold standard for kinase-substrate pairs
por: Sharifpoor, Sara, et al.
Publicado: (2012)

Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
por: Arnoldo, Anthony, et al.
Publicado: (2008)

Correction: Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
por: Arnoldo, Anthony, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_6krhut5t7gphaq7ddiebo3o4jd